文献类型：期刊文献

英文题名：Surface Modification of Reduced Graphene Oxide Beads: Integrating Efficient Endotoxin Adsorption and Improved Blood Compatibility

作者：Li, Zhentao[1];Yan, Xin[1];Wu, Keke[1];Jiao, Yanpeng[1];Zhou, Changren[1];Yang, Jingxin[2]

第一作者：Li, Zhentao

通讯作者：Jiao, YP[1]

机构：[1]Jinan Univ, Dept Mat Sci & Engn, Guangzhou 510632, Peoples R China;[2]Beijing Union Univ, Coll Robot, Beijing 100027, Peoples R China

第一机构：Jinan Univ, Dept Mat Sci & Engn, Guangzhou 510632, Peoples R China

通讯机构：[1]corresponding author), Jinan Univ, Dept Mat Sci & Engn, Guangzhou 510632, Peoples R China.

年份：2021

卷号：4

期号：6

起止页码：4896-4906

外文期刊名：ACS APPLIED BIO MATERIALS

收录：EI(收录号：20212210416590);Scopus(收录号：2-s2.0-85106458419);WOS:【ESCI(收录号:WOS:000664594300021)】；

基金：This work was supported by the National Key R&D Program of China (grant no. 2018YFC0311103), Science and Technology Project of Guangzhou City (grant no. 201802010066), and International Project of Development zone of Guangzhou City (grant no. 2018GH11).

语种：英文

外文关键词：graphene; beads; polymyxin B; heparin; adsorption; endotoxin

摘要：As a pathogenic toxin, endotoxins are the culprit for endotoxemia and can be generally removed from the blood by hemoperfusion. Reduced graphene oxide (rGO) is a promising endotoxin sorbent for hemoperfusion owing to its excellent adsorption capacity, but it has the side effect of nonspecific adsorption and low blood compatibility. Polymyxin B (PMB) acts as an organic affinity ligand that can specifically bind endotoxins. As a natural anticoagulant, heparin (Hep) can reduce the risk of coagulation and improve the blood compatibility of materials. Herein, an rGO bead adsorbent was prepared by coupling with PMB and Hep and used for endotoxin adsorption; in this, polydopamine (pDA) served as an active coating for immobilization of PMB and further coupling with Hep. The physicochemical characteristics indicated that PMB and Hep were successfully immobilized on rGO beads with a hierarchical pore structure. PMB endowed rGO beads with higher adsorption capacity (143.84 +/- 3.28 EU/mg) and good adsorption selectivity for endotoxins. Hep significantly improved the blood compatibility of rGO beads. These modified rGO beads also achieved good adsorption capacity and adsorption selectivity for endotoxins in plasma, serum, or blood. Therefore, rGO/pDA/PMB/Hep beads are potential adsorbents for endotoxins in hemoperfusion.