文献类型：期刊文献

英文题名：A new 2H-benzindazole compound from Alternaria alternata Shm-1, an endophytic fungus isolated from the fresh wild fruit of Phellinus igniarius

作者：Wu, Xiuli[1];Wang, Sa[1];Liu, Cheng[1];Zhang, Caifang[1];Guo, Jinjing[1];Shang, Xiaoya[2]

第一作者：Wu, Xiuli

通讯作者：Wu, XL[1];Shang, XY[2]

机构：[1]Ningxia Med Univ, Key Lab Hui Ethn Med Modernizat, Ningxia Engn & Technol Res Ctr Modern Hui Med, Coll Pharm,Minist Educ, Yinchuan 750004, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：Ningxia Med Univ, Key Lab Hui Ethn Med Modernizat, Ningxia Engn & Technol Res Ctr Modern Hui Med, Coll Pharm,Minist Educ, Yinchuan 750004, Peoples R China

通讯机构：[1]corresponding author), Ningxia Med Univ, Key Lab Hui Ethn Med Modernizat, Ningxia Engn & Technol Res Ctr Modern Hui Med, Coll Pharm,Minist Educ, Yinchuan 750004, Peoples R China;[2]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2019

卷号：73

期号：3

起止页码：620-626

外文期刊名：JOURNAL OF NATURAL MEDICINES

收录：;Scopus(收录号：2-s2.0-85062960453);WOS:【SCI-EXPANDED(收录号:WOS:000469229900022)】；

基金：The authors are grateful to Prof. Z. G. Yue for the collection of fresh fruit of P. igniarius. The project was financially supported by the National Natural Science Foundation of China (NNSFC; Grant nos: 81260477 and 81560567).

语种：英文

外文关键词：Alternaria alternata Shm-1; Alterindazolin A; Phellinus igniarius; Antibacterial activity

摘要：Endophytic fungi have been shown in recent years to produce a series of bioactive secondary metabolites. Several endophytic fungi were isolated from the fresh wild body of Phellinus igniarius, and initially evaluated for their antimicrobial activity. Among which, Shm-1 extract showed moderate inhibitory activity against Clavibacter michiganense and the fungus was identified to be Alternaria alternata Shm-1 through the comparison of morphological characteristics and the sequence of the rDNA ITS with those of other Alternaria species. A new 2H-benzindazole derivative, alterindazolin A (1), has been isolated from cultures of the endophyte Alternaria alternata Shm-1. Its structure was characterized as 1-benzyl-5-p-hydroxy-phenyloxygen-benz[e]indazole by spectroscopic data analysis including 1D NMR, 2D NMR and MS spectrum.