文献类型：期刊文献

中文题名：Encapsulation of Antarctic krill oil in alginate-gelatin hydrogel alleviates hyperlipidemia in high-fat-diet fed rats

作者：Xuan Ma[1];Yiming Wei[1];Yi He[1];Chenrui Zhao[1];Qin Chen[1];Bo Liu[1];Tao Wei[1];Wenjie Yan[1];Feng Wang[1,2]

第一作者：Xuan Ma

机构：[1]College of Biochemical Engineering,Beijing Union University,Beijing 100023,China;[2]Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Beijing 100193,China

第一机构：北京联合大学生物化学工程学院

年份：2026

卷号：15

期号：1

起止页码：253-262

中文期刊名：Food Science and Human Wellness

外文期刊名：食品科学与人类健康(英文)

基金：funded by the National Key Research and Development Program of China(2023YFF1103804);the Academic Research Projects of Beijing Union University(ZK20202516).

语种：英文

中文关键词：Krill oil;Microcapsule;Alginate,gelatin;High-fat diet

摘要：Krill oil is effective in reducing blood lipid levels,particularly in individuals with severe hyperlipidemia.However,poor water insolubility and stability limited its usage.This study investigated a method for encapsulating Antarctic krill oil using alginate(ALG)and gelatin(GLN)to enhance its stability and bioactivity.The encapsulation efficiency,functional group integrity,swelling rate,and lipid-lowering activity were assessed.Results indicated that the optimal encapsulation conditions were identified with an ALG:GLN ratio of 2:1(m/m),coagulation bath of 9%CaCl_(2),and a nozzle size of 750μm,resulting in 69.34%encapsulation efficiency.Fourier-transform infrared spectroscopy confirmed successful encapsulation.The ALG-GLN shell materials enriched astaxanthin in krill oil and protected it from harsh gastric conditions,enabling targeted intestinal release.In a high-fat diet-induced rat model,krill oil microcapsules significantly reduced triglycerides(TG),total cholesterol(TC),and low-density lipoprotein-cholesterol(LDL-C)levels while increasing high-density lipoprotein-cholesterol(HDL-C)levels compared to unencapsulated krill oil.Additionally,the microcapsules elevated nitric oxide(NO)levels,enhanced superoxide dismutase(SOD)activity,and reduced malondialdehyde(MDA)levels,liver and perirenal fat weight.Therefore,encapsulating Antarctic krill oil in alginate-gelatin hydrogel offers a promising strategy for managing hyperlipidemia and associated metabolic disorders.