文献类型：期刊文献

英文题名：Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

作者：Guo, Jinhong[1];Yan, Wenjie[1];Duan, Hao[1];Wang, Diandian[1];Zhou, Yaxi[1];Feng, Duo[2];Zheng, Yue[3];Zhou, Shiqi[1];Liu, Gaigai[1];Qin, Xia[4]

第一作者：Guo, Jinhong

通讯作者：Qin, X[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, Beijing 100023, Peoples R China;[2]Minist Agr & Rural Affairs, Inst Food & Nutr Dev, Beijing 100081, Peoples R China;[3]Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Peoples R China;[4]Beijing Union Univ, Grad Dept, Beijing 100101, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Grad Dept, Beijing 100101, Peoples R China.|[11417]北京联合大学;

年份：2024

卷号：16

期号：11

外文期刊名：NUTRIENTS

收录：;Scopus(收录号：2-s2.0-85196600763);WOS:【SCI-EXPANDED(收录号:WOS:001245535000001)】；

基金：This work was supported by the National Key Research and Development Program of China [2023YFF1103802].

语种：英文

外文关键词：natural products; liver cancer; therapeutic drugs; mechanisms of action

摘要：Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting a growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, and minimal side effects. This paper begins by reviewing existing treatment methods and drugs for liver cancer. It then summarizes the therapeutic effects of NPs sourced from various origins on liver cancer. Finally, we analyze the potential mechanisms of NPs in treating liver cancer, including inhibition of angiogenesis, migration, and invasion; regulation of the cell cycle; induction of apoptosis, autophagy, pyroptosis, and ferroptosis; influence on tumor metabolism; immune regulation; regulation of intestinal function; and regulation of key signaling pathways. This systematic review aims to provide a comprehensive overview of NPs research in liver cancer treatment, offering a foundation for further development and application in pharmaceuticals and functional foods.