文献类型：期刊文献

英文题名：Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

作者：Tian, Yuxin[1];Liu, Weirui[1];Lu, Yi[2];Wang, Yan[1];Chen, Xiaoyi[1];Bai, Shaojuan[1];Zhao, Yicheng[1];He, Ting[1];Lao, Fengxue[3];Shang, Yinghui[3];Guo, Yu[3];She, Gaimei[1]

第一作者：Tian, Yuxin

通讯作者：She, GM[1]

机构：[1]Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing 100102, Peoples R China;[2]Beijing Univ Chinese Med, Sch Basic Med, Beijing 100102, Peoples R China;[3]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing 100102, Peoples R China

通讯机构：[1]corresponding author), Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing 100102, Peoples R China.

年份：2016

卷号：21

期号：10

外文期刊名：MOLECULES

收录：;Scopus(收录号：2-s2.0-84994034072);WOS:【SCI-EXPANDED(收录号:WOS:000389917900139)】；

基金：The authors gratefully acknowledge the financial support of the National Natural Science Foundation of China grant No. 81573692), National Natural Science Foundation of China grant No. 8157140862), the Beijing Nova Program (grant No. 2011070), the Self-selected Topic of Beijing University of Chinese Medicine (grant No. 2015-JYB-JSMS024), the Beijing Nova Program (No. Z121102002512045).

语种：英文

外文关键词：cinnamic acid sugar ester derivatives; phytochemistry; pharmacological activity; traditional Chinese medicine

摘要：Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3',6-disinapoylsucrose, the index component of Yuanzhi (a well-known Traditional Chinese Medicine or TCM), presents antidepressant effects at a molecular level, and has become a hotspot of research on new lead drug compounds. Several other similar cinnamic acid sugar ester derivatives are reported in traditional medicine as compounds to calm the nerves and display anti-depression and neuroprotective activity. Interestingly, more than one third of CASEDs are distributed in the family Polygalaceae. This overview discusses the isolation of cinnamic acid sugar ester derivatives from plants, together with a systematic discussion of their distribution, chemical structures and properties and pharmacological activities, with the hope of providing references for natural product researchers and draw attention to these interesting compounds.