文献类型：期刊文献

英文题名：Evaluation of Alveolar Bone Repair with Mineralized Collagen Block Reinforced with Mg-Ca Alloy Rods

作者：Guo, Chang-Wu[1];Yu, Qing[1];Sun, Bao-Zhai[1];Wang, Cheng-Yue[2];Yang, Jing-Xin[3]

第一作者：Guo, Chang-Wu

通讯作者：Wang, CY[1];Yang, JX[2]

机构：[1]JinZhou Med Univ, Affiliate Stomatol Hosp, Jinzhou 121000, Liaoning, Peoples R China;[2]JinZhou Med Univ, Dept Prosthodont, Affiliate Stomatol Hosp, Jinzhou 121000, Liaoning, Peoples R China;[3]Beijing Union Univ, Coll Robot, Beijing 100101, Peoples R China

第一机构：JinZhou Med Univ, Affiliate Stomatol Hosp, Jinzhou 121000, Liaoning, Peoples R China

通讯机构：[1]corresponding author), JinZhou Med Univ, Dept Prosthodont, Affiliate Stomatol Hosp, Jinzhou 121000, Liaoning, Peoples R China;[2]corresponding author), Beijing Union Univ, Coll Robot, Beijing 100101, Peoples R China.|[1141739]北京联合大学机器人学院;[11417]北京联合大学;

年份：2018

卷号：8

期号：1

起止页码：1-10

外文期刊名：JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000426615200001)】；

基金：This research was supported by The Science and Technology Fund of Liaoning Province (No. 2015020689), Premium Funding Project for Academic Human Resources Development in Beijing Union University and 2017 Improve the Level of Scientific Research: Quota-Oriented Features of Discipline Research Projects by Beijing Union University (Grant No. KYDE40201708). The authors thank Mr. T. X. Song for giving help and suggestion on the materials fabrication and Ms. Y. J. Chen, Mr. Y. Chen, Mr. B. Z. Kang, Mr. S. N. Jin and Mr. X. G. Guo for their generous assistance.

语种：英文

外文关键词：Mg-Ca Alloy; Mineralized Collagen; Bone Reconstruction; Bone Graft Composite

摘要：To evaluate the feasibility of the composite of MC block reinforced with Mg-Ca alloy rods for bone reconstruction in dogs. The buccal plates of bilateral mandibular third and fourth premolars were removed to form 5 (width) x5 ( height) x16 (length) mm defect following the healing of the extractions of the third and fourth premolars. All dogs were randomly divided into A, B, C three groups. Group A was implanted with the composites, group B was implanted with mineralized collagen blocks, and group C, blank control group. The bone-repairing ability was separately analyzed by radiological, histological evaluation at 12th week and 24th week postoperatively respectively. For hematological evaluation, Serum Mg2+ concentrate was sampled before the operation day as the baseline, and at 1st, 2nd, 4th, 6th, 8th and 12th week, respectively. New bone width of group A and B was wider than group C at 12th week (P < 0.05). However, no difference was found in new bone width and height between group A and B at 12th and 24th week. The composite had similar results in BV/TV (%) with mineralized collagen (p > 0.05). The hematological results indicated the safety of the releasing of Mg2+. This study shows composite is safe, could maintain a large osteogensis space and accelerate new bone formation, but does not seem to achieve the desired effect in repairing the alveolar ridge of the buccal bone defects.