文献类型：期刊文献

英文题名：Highland red rice-derived resistant starch and pigment extracts exert combined anti-hyperglycemic effects via the gut microbiota-PYY/ GLP-1 pathway

作者：Zhao, Leyi[1];Shao, Xinyu[1];Wang, Liyuan[1];Cheng, Ziqing[1];Zeng, Yawen[2];Si, Shiquan[3];Yang, Xuhua[3];Li, Xia[2];Yang, Xiaomeng[2];Ye, Lina[1];Peng, Yuji[1];Zhang, Michael[4];Li, Zuming[1]

通讯作者：Li, ZM[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China;[2]Yunnan Acad Agr Sci, Biotechnol & Germplasm Resources Inst, Kunming 650205, Peoples R China;[3]Lijiang Ninglang Yikang Agr Prod Dev Co Ltd, Lijiang 674309, Peoples R China;[4]Univ Manitoba, Dept Phys & Astron, Winnipeg, MB R3T 2N2, Canada

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2026

卷号：79

外文期刊名：FOOD BIOSCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001737725800001)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 31760376); National Key Assistance County Cluster Assistance Project of Lijiang Science and Technology Bureau (2022LJZTBF001); 'Qimingxing' Science and Technology Innovation Project Fund (20051055) and Lijiang Ninglang Yikang Agricultural Products Development Co., Ltd Cooperation Project (50304JA2337).

语种：英文

外文关键词：Highland red rice resistant starch; Antidiabetic; Gut microbiota-PYY/GLP-1 pathway

摘要：Highland red rice from southwestern China is recognized as a health-promoting grain, but its potential in diabetes management remains underexplored. In this study, resistant starch (RS) and pigment extracts (RP) were isolated from highland red rice to determine whether they act in combination to modulate gut microbiota and metabolism in streptozotocin (STZ)-induced diabetic mice, with the aim of elucidating the mechanisms underlying their anti-hyperglycemic effects. Neither RS nor RP single interventions significantly improved key glycemic parameters; however, the combined intervention (RSP) significantly reduced fasting blood glucose (FBG) levels and improved glucose tolerance. 16S rRNA analysis indicated RSP intervention increased the abundance of short-chain fatty acid (SCFA)-producing bacteria, including Lactobacillus, Lactococcus, Akkermansia, and Romboutsia, while decreasing pro-inflammatory taxa such as Candidatus_Arthromitus. Metabolomic analysis revealed RSP intervention elevated levels of cholic acid (CA), hyocholic acid (HCA), and sphingolipid metabolism intermediates (sphingosine and sphinganine). Crucially, both SCFA concentrations and the expression of peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) were significantly elevated after RSP intervention. These findings demonstrate that RS and RP together exert combined anti-hyperglycemic effects by modulating gut microbiota and its metabolites, thereby activating the PYY/GLP-1 signaling. This highlights the therapeutic potential of highland red rice components in diabetes management.