文献类型：期刊文献

英文题名：Bifidobacterium longum subsp. infantis YLGB-1496-Toxicological evaluation

作者：Zhao, Jian[1];Guo, Yueyi[1];Jiang, Qiuyue[2];Lan, Hanglian[2];Hung, Wei-Lian[2];Lynch, Barry[3]

第一作者：赵建

通讯作者：Hung, WL[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[2]Natl Ctr Technol Innovat Dairy, Hohhot, Peoples R China;[3]Intertek Hlth Sci Inc, Mississauga, ON, Canada

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Natl Ctr Technol Innovat Dairy, 8 West Guochuang Rd, Hohhot 010110, Inner Mongolia, Peoples R China.

年份：2024

外文期刊名：JOURNAL OF APPLIED TOXICOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001309233400001)】；

基金：Financial support for the conduct of the studies and preparation of the manuscript (Intertek Health Sciences Inc, Mississauga, Canada) was provided by Inner Mongolia Yili Industrial Group Co., Ltd. and National Center of Technology Innovation for Dairy (No. 2020-KJXM-GCZX-1).

语种：英文

外文关键词：< fixed-case > Bifidobacterium longum ; probiotic; safety; toxicology; genotoxicity

摘要：Bifidobacterium infantis YLGB-1496, originally isolated from breast milk from a Taiwanese mother, is under study for use as a probiotic. As part of safety assessment, an Ames, in vivo mouse micronucleus, and in vivo mouse spermatocyte chromosome aberration assay were conducted along with a 13-week oral rat toxicity study. B. infantis YLGB-1496 had no activity in any of the genotoxicity assays. Administration of the bacteria to Sprague-Dawley rats at doses ranging from 0 to 1.5 g/kg bw/day had no treatment-related effects on any of the endpoints measured. There appear to be no concerns for translocation or pathogenicity of B. infantis YLGB-1496 based on extensive experience with the species in general. The results of the current investigations support potential use of B. infantis YLGB-1496 as a probiotic in infant formula.