文献类型：期刊文献

英文题名：Two protein-derived peptides from Bombyx mori attenuate colitis by enhancing intestinal barrier function and modulating gut microbiota ecology

作者：Zhou, Yaxi[1];Wang, Diandian[1];Guo, Jinhong[1];Zheng, Yue[2];Duan, Hao[1];Yan, Wenjie[1]

第一作者：Zhou, Yaxi

通讯作者：Yan, WJ[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing Key Lab Bioact Subst & Funct Food, Beijing 100023, Peoples R China;[2]Northwest A&F Univ, Coll Food Sci & Engn, Xianyang, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing Key Lab Bioact Subst & Funct Food, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2024

外文期刊名：FOOD FRONTIERS

收录：EI(收录号：20243616986959);Scopus(收录号：2-s2.0-85202801602);WOS:【ESCI(收录号:WOS:001303938700001)】；

基金：This work was supported by the National Key Research and Development Program of China (grant number 2023YFF1103802).

语种：英文

外文关键词：bioactive peptides; gut microbiota; inflammation; intestinal barrier; short-chain fatty acids; ulcerative colitis

摘要：Food-sourced proteins have been shown to have ameliorative effects on ulcerative colitis (UC), and studies have identified potential anti-inflammatory activity of silkworm pupa proteins. Here, we identified and screened two novel protein-derived peptides, PDLGLF (PD-6) and GTEGGFPF (GT-8), from Bombyx mori using UPLC-MS/MS and bioinformatics analysis. These peptides can serve as effective experimental drugs for colitis by modulating the gut microbiota. Treatment with peptides PD-6 and GT-8 inhibited colitis inflammation in UC mice, improved oxidative stress levels, and maintained intestinal epithelial barrier function. Peptides PD-6 and GT-8 also altered the diversity and composition of the gut microbiota in UC mice and increased the concentration of short-chain fatty acids. In conclusion, these findings reveal the potential of the naturally derived bioactive peptides PD-6 and GT-8 in controlling intestinal inflammation and underscore the potential of PD-6 and GT-8 as promising candidates for the prevention and improvement of UC-related inflammatory diseases.