文献类型：期刊文献

英文题名：Anti-apoptotic Effect of Grape Seed Proanthocyanidin Extract on Cisplatin-induced Apoptosis in Rat Testis

作者：Zhao, Yanmeng[1];Zhang, Hailian[1];Gao, Liping[1]

第一作者：Zhao, Yanmeng

通讯作者：Gao, LP[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2015

卷号：21

期号：6

起止页码：805-811

外文期刊名：FOOD SCIENCE AND TECHNOLOGY RESEARCH

收录：;EI(收录号：20160801983292);Scopus(收录号：2-s2.0-84958238049);WOS:【SCI-EXPANDED(收录号:WOS:000366151700008)】；

基金：This work was supported by grants from Scientific Research Project of Beijing Union University: Opening Project of Key Laboratory (NO.Zk70201502).

语种：英文

外文关键词：cisplatin; grape seed proanthocyanidins; testis; Apoptosis

摘要：This study was to investigate the possible anti-apoptotic effect of grape seed proanthocyanidin extract (GSPE) on cisplatin (CDDP)-induced testicular apoptosis in male rats. The control group was treated with physiological saline, the GSPE (400 mg/kg) group, GSPE (200 mg/kg) + CDDP group and GSPE (400 mg/kg) + CDDP group were received GSPE orally at corresponding dose respectively, for 15 consecutive days, starting 10 days before a single intraperitoneal dose of CDDP (7 mg/kg) in CDDP group and GSPE + CDDP groups. Administration of CDDP significantly reduced the weight of testis and epididymis, sperm concentration and caused significantly increase in the apoptosis rate of testicular cells and expression of Bax and Caspase-3, decrease in the expression of Bcl-2, along with some histopathological lesions in testicular tissue. Therefore, pre-treatment of GSPE to CDDP-injected rats tend to prevent CDDP-induced lose weight of organs, testicular apoptosis and histopathological lesions. Presented data have documented GSPE have improvement effects against testicular apoptosis caused by CDDP.