文献类型：期刊文献

英文题名：Nostoc sphaeroids Kutz ameliorates hyperlipidemia and maintains the intestinal barrier and gut microbiota composition of high-fat diet mice

作者：Wei, Fenfen[1,2];Liu, Yinlu[1,2];Bi, Cuicui[1,2];Chen, Sheng[3];Wang, Yulan[3];Zhang, Bo[1,2]

第一作者：Wei, Fenfen

通讯作者：Zhang, B[1]

机构：[1]Beijing Union Univ, Res Inst Sci & Technol Funct Foods, Beijing, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[3]Hunan Yandi Bioengn Co Ltd, Zhuzhou, Peoples R China

第一机构：北京联合大学

通讯机构：[1]corresponding author), Beijing Union Univ, Res Inst Sci & Technol Funct Foods, Beijing, Peoples R China.|[11417]北京联合大学;

年份：2020

卷号：8

期号：5

起止页码：2348-2359

外文期刊名：FOOD SCIENCE & NUTRITION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000525884400001)】；

基金：Hunan Yandi Bioengineering Co., Ltd

语种：英文

外文关键词：gut microbiota; hyperlipidemia; inflammation; Nostoc sphaeroids Kutz; short-chain acids

摘要：Hyperlipidemia is associated with chronic inflammation and intestinal dysbiosis. The purpose of this study was to investigate the protective effect of Nostoc sphaeroids Kutz (NO) on diet-induced hyperlipidemia in mice. Experimental animals received a high-fat diet (HFD) for 4 weeks, then an HFD supplemented with 2.5% or 7.5% NO for 6 weeks. HFD-fed mice exhibited a significant increase in serum total cholesterol, triglycerides, and low-density lipid cholesterol, and a decrease in high-density lipid cholesterol. NO supplementation was associated with significantly lower dyslipidemia, decreased intestinal inflammation, and inhibition of toll-like receptor 4 gene repression in HFD-fed mice. Results suggest that NO treatment protected the integrity of the intestinal barrier. NO treatment was also associated with significant changes in the intestinal microbiota induced by HFD and an increase in the Firmicutes-to-Bacteroidetes ratio. Furthermore, NO treatment was also inversely correlated with mice obesity and hyperlipidemia NO and was associated with no significant in fecal short-chain fatty acids. In conclusion, NO significantly ameliorated hyperlipidemia induced by a HFD in mice, potentially via a decrease intestinal inflammation, increase in intestinal barrier integrity, and amelioration in the gut microbiota.