文献类型：期刊文献

英文题名：Anti-inflammatory iridoid glycosides from fruits of Cornus officinalis

作者：Wang, Xin[1];Wu, Yong[1];Wang, Ze-yu[1];Li, Jin-jie[1];Li, Wen[1];Li, Qian[2];Luan, Na[1];Shang, Xiao-ya[1]

第一作者：王欣

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Henan Agr Univ, Coll Food Sci & Technol, Zhengzhou 450002, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2022

卷号：52

起止页码：122-125

外文期刊名：PHYTOCHEMISTRY LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000891831200003)】；

基金：Acknowledgements This work was supported by the Beijing Natural Science Foundation (No. 7214280) and Henan Agricultural University Science and Tech- nology Innovation Fund (KJCX2021A19) .

语种：英文

外文关键词：Cornus officinalis; Iridoid glycosides; Anti-inflammatory activity

摘要：Three undescribed iridoid glycosides, cyc(7 beta-O-6 ')-morroniside (1), 6 '-methyl succinate-7 beta-O-methylmorroniside (2), and 7 beta-O-methyl phenyllactate morroniside (3) were isolated from 50% ethanol extract of Cornus officinalis fruits. The structures of the isolated compounds were determined by HRESIMS, 1D NMR, 2D NMR, UV and IR spectroscopic methods. Compounds 1-3 exhibited moderate anti-inflammatory activities in vivo in a CuSO4- induced zebrafish inflammation model (when evaluated at 50 mu M).