文献类型：期刊文献

英文题名：Dual-Mode Imaging-Guided Synergistic Chemo- and Magnetohyperthermia Therapy in a Versatile Nanoplatform To Eliminate Cancer Stem Cells

作者：Tang, Jinglong[1,2,3];Zhou, Huige[1,2,3];Liu, Jiaming[1,2,3];Liu, Jing[1,2,3];Li, Wanqi[1,2];Wang, Yuqing[1,2];Hu, Fan[4];Huo, Qing[4];Li, Jiayang[1,2];Liu, Ying[1,2];Chen, Chunying[1,2,3]

第一作者：Tang, Jinglong

通讯作者：Chen, CY[1];Chen, CY[2];Chen, CY[3]

机构：[1]Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China;[2]Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China;[3]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[4]Beijing Union Univ, Dept Biomed, Coll Biochem Engn, Beijing 100023, Peoples R China

第一机构：Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

通讯机构：[1]corresponding author), Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China;[2]corresponding author), Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China;[3]corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

年份：2017

卷号：9

期号：28

起止页码：23497-23507

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20173003966034);Scopus(收录号：2-s2.0-85024851609);WOS:【SCI-EXPANDED(收录号:WOS:000406172700024)】；

基金：This work was financially supported by the Ministry of Science and Technology of China (National Basic Research Program 2016YFA0201600), the National Natural Science Foundation of China (21320102003, 21403043), the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (11621505), the CAS Key Research Program for Frontier Sciences (QYZDJ-SS-SLH022), the CAS Interdisciplinary Innovation Team and the National Science Fund for Distinguished Young Scholars (11425520).

语种：英文

外文关键词：Fe3O4@PPr@HA hybrid nanoparticles; DAPT; photoacoustic imaging; magnetic resonance imaging; cancer stem cells

摘要：Cancer stem cells (CSCs) have been identified as a new target for therapy in diverse cancers. Traditional therapies usually kill the bulk of cancer cells, but are often unable to effectively eliminate CSCs, which may lead to drug resistance and cancer relapse. Herein, we propose a novel strategy: fabricating multifunctional magnetic Fe3O4@PPr@HA hybrid nanoparticles and loading it with the Notch signaling pathway inhibitor N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycinet-butylester (DAFT) to eliminate CSCs. Hyaluronic acid ligands greatly enhance the accumulation of the hybrid nanoparticles in the tumor site and in the CSCs. Both hyaluronase in the tumor microenvironment and the magnetic hyperthermia effect of the inner magnetic core can accelerate the release of DAPT. This controlled release of DAPT in the tumor site further enhances the ability of the combination of chemo- and magnetohyperthermia therapy to eliminate cancer stem cells. With the help of polypyrrole-mediated photoacoustic and Fe3O4-mediated magnetic resonance imaging, the drug release can be precisely monitored in vivo. versatile nanoplatform enables effective elimination of the cancer stem cells and monitoring of the drugs. This