文献类型：会议论文

英文题名：Biomedical Imaging and Visualization Model of Mitochondrial Dysfunction and Oxidative stress in Alzheimer Disease

作者：Lin, Chang-Jun[1];Huang, Han-Chang[1];Liu, Wen-Juan[1];Jiang, Zhao-Feng[1]

第一作者：Lin, Chang-Jun

通讯作者：Lin, CJ[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Coll Arts & Sci, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Coll Arts & Sci, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

会议论文集：2nd International Conference on Applied Mechanics and Mechanical Engineering (ICAMME 2011)

会议日期：OCT 08-09, 2011

会议地点：Sanya, PEOPLES R CHINA

语种：英文

外文关键词：Alzheimer's disease; Mitochondrial membrane potential; Ca2+; Chromatin Condensation; ROS

摘要：Mitochondrial dysfunction and oxidative stress are among the earliest events linked to Alzheimer Disease and might play a causative role in disease onset and progression. In this paper, a biomedical imaging and visualization model was set to investigate the mitochondrial dysfunction and oxidative stress in A beta/Cu2+-treated cells, which contribute in a significant manner to bioenergetic failure and mitochondrial dysfunction, by measuring mitochondrial membrane potential, Ca2+, chromatin condensation and ROS. This evaluating method opens a window for analyzing the protective effect of a certain substance in improving mitochondrial function and preventing oxidative stress in AD development.