文献类型：期刊文献

中文题名：青蒿素脂质体的制备及质量评价

英文题名：Preparation and Quality Evaluation of Artemisinin Liposomes

作者：瞿建江[1];冯淑华[2];李可意[2]

第一作者：瞿建江

机构：[1]扬州大学医学院;[2]北京联合大学生物化学工程学院

第一机构：扬州大学医学院,江苏扬州225001

年份：2011

卷号：28

期号：3

起止页码：251-256

中文期刊名：中国现代应用药学

外文期刊名：Chinese Journal of Modern Applied Pharmacy

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：青蒿素;脂质体;包封率;质量评价

外文关键词：artemisinin; liposomes; trapping efficiency; quality evaluation

摘要：目的通过对青蒿素脂质体的处方和制备工艺研究,研制高包封率和稳定的脂质体。方法采用乙醇注入法制备脂质体,以正交实验优化处方。测定了脂质体中药物的包封率;并初步考察了脂质体的稳定性。结果优化处方与工艺所得脂质体形态均匀,包封率>85%,载药量达27.22%,粒径约为90 nm,Zeta电位约为-68.4 mV,具有良好的稳定性。结论乙醇注入法制备脂质体工艺简便,包封率高,制备的脂质体稳定性好。
OBJECTIVE To get a stable artemisinin liposome with high trapping efficiency by selecting formulation and preparation of artemisinin liposome. METHODS The artemisinin liposomes were prepared by film-ultrasound method. The formulation was optimized by orthogonal design. The trapping efficiency and the stability were determined. RESULTS The trapping efficiency of the artemisinin liposome reached 85%, the drug amounted to 27,22%, the particle size of the liposome was 90 nm and the Zeta potential was -68.4 mV. The liposome had good stability. CONCLUSION The method can be used to prepare a stable artemisinin liposome with high trapping efficiency.