文献类型：期刊文献

英文题名：Immunometabolic Reprogramming in Experimental Sepsis: A Driver of Multiple Organ Dysfunction Syndrome

作者：Wu, Fan[1];Chen, Yantong[1];Chen, Lihua[2];Wei, Xiaolu[2];Zhang, Lin[1];Shen, Yi[1]

第一作者：吴凡

通讯作者：Shen, Y[1]

机构：[1]Beijing Union Univ, Special Educ Coll, Beijing, Peoples R China;[2]China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China

第一机构：北京联合大学特殊教育学院

通讯机构：[1]corresponding author), Beijing Union Univ, Special Educ Coll, Beijing, Peoples R China.|[1141759]北京联合大学特殊教育学院;[11417]北京联合大学;

年份：2026

卷号：19

外文期刊名：JOURNAL OF INFLAMMATION RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001707506900001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Scientific and technological innovation project of China Academy of Chinese Medical Sciences (CI2023C020YL, CI2023E001TS09).

语种：英文

外文关键词：experimental sepsis; multiple organ dysfunction syndrome; immunometabolic reprogramming; inter-organ crosstalk; glycolysis

摘要：Sepsis is a life-threatening syndrome characterized by infection-induced systemic inflammation and immune dysregulation, commonly resulting in the development of multiple organ dysfunction syndrome (MODS), a leading cause of mortality in clinical practice. In decades, immunometabolic reprogramming has been identified as a critical mechanism that contributes to the progression of sepsis and the associated organ injuries. The review provides a systematic overview of the metabolic alterations in immune cells and organs in experimental models of sepsis. Key features include enhanced glycolysis, impaired mitochondrial function, and disturbed lipid metabolism, all of which are closely associated with organ damage. These metabolic adaptations influence immune responses and cell fate decisions, inter-organ crosstalk, and the development of MODS. A detailed examination is conducted on the temporal progression of pathological changes in established animal models, along with organ-specific metabolic dysfunctions and novel therapeutic targets. It emphasizes the importance of dynamic immunometabolic regulation, tissue-specific responses, and inter-organ interactions in the context of sepsis treatment. The integration of multi-omics technologies, identification of reliable biomarkers, and the development of personalized therapeutic strategies should be used to facilitate clinical translation of mechanistic insights.