文献类型：期刊文献

英文题名：Lactobacillus Combined with Inulin Ameliorated Memory Deficit by Modulating Gut Microbiota and Metabolic Profiles

作者：Shao, Xinyu[1];Cheng, Ziqing[1];Zhao, Leyi[1];Niu, Xiaohui[1];Zhang, Michael[2,3];Guo, Lei[1];Li, Zuming[1];Hao, Lei[4];Quan, Huanhuan[4]

第一作者：Shao, Xinyu

通讯作者：Li, ZM[1];Hao, L[2];Quan, HH[2]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[2]Univ Manitoba, Dept Phys & Astron, Winnipeg, MB, Canada;[3]Sino Canada Hlth Engn Res Inst, Res & Dev Dept, Hefei, Peoples R China;[4]Ordos Hlth Examinat Ctr, Med Dept, Ordos 017000, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[2]corresponding author), Ordos Hlth Examinat Ctr, Med Dept, Ordos 017000, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2025

卷号：39

期号：2

起止页码：161-184

外文期刊名：FOOD BIOTECHNOLOGY

收录：;EI(收录号：20252118491229);Scopus(收录号：2-s2.0-105005869423);WOS:【SCI-EXPANDED(收录号:WOS:001493164800004)】；

基金：This research has been carried out by Natural Science Foundation of Beijing Municipality [grant number 6173033]; Academic Research Projects of Beijing Union University [grant number ZK20202307] and Sino Canada Health Engineering Research Institute Cooperation Projects [grant number 50304JA1901].

语种：英文

外文关键词：Lactobacillus; inulin; memory deficit; gut microbiota; metabolomics

摘要：This study aimed to investigate the effects of a combination of Lactobacillus and inulin (LI) on memory impairment, gut microbiota composition, and metabolic profiles in APP/PS1 transgenic mice (MC). Mice treated with LI exhibited significant improvements in memory performance, along with marked reductions in A beta plaque deposition, neuroinflammation, and oxidative stress levels. Treatment with LI significantly increased the relative abundances of unclassified_f__Lachnospiraceae, Faecalibaculum, and Blautia, while significantly reducing Candidatus_Saccharimonas. Metabolomics analysis revealed that LI treatment led to elevated levels of acetylcholine, LysoPC (17:0), and sphinganine 1-phosphate, and a significant decrease in phosphocholine level. KEGG pathway analysis indicated that glycerophospholipid and sphingolipid metabolism were likely involved. In particular, Faecalibaculum and Candidatus_Saccharimonas may improve memory by modulating glycerophospholipid and sphingolipid pathways, respectively. These findings offer novel insights into microbiota-targeted strategies for memory enhancement.