文献类型：期刊文献

英文题名：Psychological stress leads to hepatic iron accumulation and disturbs iron homeostasis

作者：Zhao, Min[1,2]; Liu, Li-Juan[3]; Li, Xin-Guo[4]; Wang, Wan-Yin[2]; Wang, Lei[2,5]; Long, Ma[2,6]; Shen, Hui[2]; Zhu, Zhi-Ming[1]; Li, Min[2]

第一作者：Zhao, Min

通讯作者：Zhu, Zhi-Ming

机构：[1] Navy General Hospital, Beijing, China; [2] Department of Naval Medicine, Second Military Medical University, Shanghai, China; [3] Department of Health Management, Second Military Medical University, Shanghai, China; [4] College of Biochemical Engineering, Beijing Union University, Beijing, China; [5] Department of Clinical Nutrition, General Hospital of Armed Police Forces, Beijing, China; [6] Academy of Military Medical Science, Beijing, China

第一机构：Navy General Hospital, Beijing, China

年份：2014

卷号：6

期号：5

起止页码：1128-1134

外文期刊名：Journal of Chemical and Pharmaceutical Research

收录：EI(收录号：20143900070205);Scopus(收录号：2-s2.0-84907091675)

语种：英文

外文关键词：Gene expression - Iron - Liver - Oxygen

摘要：The importance of psychological stress is found in the etiology and pathology of more and more diseases. It has been reported that hepcidin is up-regulated by psychological stress, however, TFR2 is a direct regulatory role of the gene on hepcidin expression. Our aim was to evaluate the regulation of TFR2 and the series of molecular mechanisms corresponding to psychological stress. We used a communication box paradigm to induce psychological stress and found that hepatic iron increased as haemosiderin, ferritin and non–transferrin-bound iron induced by quantitative iron analysis and Perl’s staining after 7 d. Psychological stress down-regulated serum transferrin saturation and up-regulated hepatic transferrin receptor 2 after 3 d, then down-regulated hepatic transferrin receptor 1 and up-regulated hepatic ferritin mRNA/protein expression after 7 d. Simultaneously, the levels of hepatic non–transferrin-bound iron, malondialdehyde and superoxide dismutase activity all increased after 7 d. The present study suggested that TFR2 should be another regulator of hepcidin and contribute to hepatic iron accumulation. ? 2014, Journal of Chemical and Pharmaceutical Research. All rights reserved.