文献类型：期刊文献

英文题名：Clock Gene Modulates Roles of OXTR and AVPR1b Genes in Prosociality

作者：Ci, Haipeng[1];Wu, Nan[1,2];Su, Yanjie[1]

第一作者：Ci, Haipeng

通讯作者：Su, YJ[1]

机构：[1]Peking Univ, Dept Psychol, Beijing 100871, Peoples R China;[2]Beijing Union Univ, Teachers Coll, Beijing, Peoples R China

第一机构：Peking Univ, Dept Psychol, Beijing 100871, Peoples R China

通讯机构：[1]corresponding author), Peking Univ, Dept Psychol, Beijing 100871, Peoples R China.

年份：2014

卷号：9

期号：10

外文期刊名：PLOS ONE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000343210300033)】；

基金：This work was supported by the National Natural Science Foundation of China (Project 31170995, 31371040) and National Basic Research Program (973 Program: 2010CB833904). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

语种：英文

摘要：Background: The arginine vasopressin receptor (AVPR) and oxytocin receptor (OXTR) genes have been demonstrated to contribute to prosocial behavior. Recent research has focused on the manner by which these simple receptor genes influence prosociality, particularly with regard to the AVP system, which is modulated by the clock gene. The clock gene is responsible for regulating the human biological clock, affecting sleep, emotion and behavior. The current study examined in detail whether the influences of the OXTR and AVPR1b genes on prosociality are dependent on the clock gene. Methodology/Principal Findings: This study assessed interactions between the clock gene (rs1801260, rs6832769) and the OXTR (rs1042778, rs237887) and AVPR1b (rs28373064) genes in association with individual differences in prosociality in healthy male Chinese subjects (n = 436). The Prosocial Tendencies Measure (PTM-R) was used to assess prosociality. Participants carrying both the GG/GA variant of AVPR1b rs28373064 and the AA variant of clock rs6832769 showed the highest scores on the Emotional PTM. Carriers of both the T allele of OXTR rs1042778 and the C allele of clock rs1801260 showed the lowest total PTM scores compared with the other groups. Conclusions: The observed interaction effects provide converging evidence that the clock gene and OXT/AVP systems are intertwined and contribute to human prosociality.