文献类型：期刊文献

英文题名：Cardiac Cycle Phase Modulates Pain Processing During Heartbeat-Enhanced Rubber Hand Illusion

作者：Gong, Wenxiao[1,2];Xu, Qiao[2];Liang, Kun[2];Gu, Lijia[3];Chen, Lihan[2,4]

第一作者：Gong, Wenxiao

通讯作者：Chen, LH[1];Chen, LH[2]

机构：[1]Beijing Union Univ, Special Educ Coll, Beijing, Peoples R China;[2]Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China;[3]Shaoxing Univ, Ctr Brain Mind & Educ, Shaoxing, Peoples R China;[4]Peking Univ, Natl Engn Lab Big Data Anal & Applicat, Beijing, Peoples R China

第一机构：北京联合大学特殊教育学院

通讯机构：[1]corresponding author), Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China;[2]corresponding author), Peking Univ, Natl Engn Lab Big Data Anal & Applicat, Beijing, Peoples R China.

年份：2025

卷号：62

期号：10

外文期刊名：PSYCHOPHYSIOLOGY

收录：;Scopus(收录号：2-s2.0-105018648480);WOS:【SSCI(收录号:WOS:001605465100009)，SCI-EXPANDED(收录号:WOS:001605465100009)】；

基金：This work was supported by grants from the STI2030-Major Project 2021ZD0202600, Natural Science Foundation of China (T2192932), and the Academic Research Projects of Beijing Union University (No. JK202311).

语种：英文

外文关键词：body ownership illusion; cardiac cycle; interoception; pain; virtual reality

摘要：Pain-a complex, highly subjective experience-is shaped by interoceptive signals, especially the systolic and diastolic phases of cardiac rhythmicity. While body ownership illusions (BOI, the perceptual attribution of artificial limbs to one's own body) are modulated by interoceptive signals, their influence on pain processing remains controversial, with conflicting findings in the literature. Critically, it remains unclear whether cardiac-phase-specific pain modulation occurs independently of BOI. To resolve this, we examined: (1) the effects of cardiac cycles, (2) the influence of BOI, and (3) their potential interactions on pain processing. In the present study, we used a virtual reality rubber hand illusion (VR-RHI) paradigm to induce BOI. In the control condition (object, OBJ condition), participants viewed a VR scenario with an inanimate object (cardboard) instead of a rubber hand, which does not induce BOI. Pain stimulation was administered under four experimental conditions: RHI-systole, RHI-diastole, OBJ-systole, and OBJ-diastole. We assessed pain perception-thresholds, intensity and unpleasantness ratings, and somatosensory evoked potentials (SEPs)-while delivering painful electrical stimuli timed to systolic or diastolic phases under BOI and control VR conditions. Results demonstrated that compared to the systolic phase, the diastolic phase was associated with significantly lower pain intensity and unpleasantness ratings, along with reduced SEP amplitudes. However, neither BOI nor its interaction with cardiac cycle exerted significant effects on these measures. Our findings suggest that while cardiac cycle modulates pain perception, this effect operates independently of BOI.