文献类型：期刊文献

中文题名：壳聚糖的生物相容性

英文题名：Biocompatibility of chitosan

作者：李若慧[1];张雪[1];单丹彤[1];袁志奎[1]

第一作者：李若慧

机构：[1]北京联合大学生物化学工程学院

第一机构：北京联合大学生物化学工程学院

年份：2012

卷号：16

期号：12

起止页码：2237-2240

中文期刊名：中国组织工程研究

外文期刊名：Chinese Journal of Tissue Engineering Research

收录：CSTPCD;;Scopus;CSCD:【CSCD_E2011_2012】；

基金：北京市教委科研资助项目(KM200811417015)~~

语种：中文

中文关键词：壳聚糖;组织相容性;血液相容性;力学相容性;生物材料

摘要：背景:壳聚糖是惟一一种被广泛应用于生物医学工程领域的碱性、带有正电荷的天然多糖,其生物相容性是决定这些应用价值的关键。目的:综述了壳聚糖的生物相容性,包括组织相容性、血液相容性和力学相容性。方法:由第一作者检索1990/2011PubMed数据库、中国知网数据库及万方数据库有关壳聚糖及其衍生物在生物医学上的应用和生物相容性等方面的文献。结果与结论:壳聚糖作为可生物降解高分子材料具有良好的组织相容性及与人体组织相匹配所需要的力学相容性,被逐渐应用于人工皮肤、手术缝合线、眼科修复、人工骨骼、牙齿修复、肿瘤治疗等方面。但壳聚糖的促凝血作用使其血液相容性很差,目前很多研究关注于寻找解决这一问题的方法,改善其血液相容性,扩展其在生物医学工程上的应用领域,使其更加安全有效地与人体心血管系统直接接触。
BACKGROUND：Chitosan is a kind of nature polysaccharide which recently has been widely applied in biomedical field as its unique alkaline and positive charges that are critically depending on its biocompatibility.OBJECTIVE：To summarize the biocompatibility of chitosan as well as its histocompatibility,blood compatibility and mechanical compatibility.METHODS：The databases of PubMed,CNKI and Wanfang（1990-2011） were used to search the related articles about the biocompatibility of chitosan and its derivant and the applications on biomedicine.RESULTS AND CONCLUSION：Chitosan as a kind of biodegradable polymer materials has been gradually applied on artificial skin,operation suture,ophthalmology,artificial skeleton,oral rehabilitation and tumor therapy depended on its good histocompatibility and mechanical compatibility which was used to match human body organization.However,the blood compatibility of chitosan was poor due to its thrombosis.To date,many studies are focus on the solution to this problem,improve the blood compatibility and expand the application on biomedicine filed in order to make it more safety and effectively to contact with cardiovascular system.