文献类型：期刊文献

英文题名：A review on the exploitation of biodegradable magnesium-based composites for medical applications

作者：Yang, Jingxin[1,2,3];Koons, Gerry L.[3];Cheng, Guang[1,2];Zhao, Linhui[1,2];Mikos, Antonios G.[3];Cui, Fuzhai[4]

第一作者：Yang, Jingxin;杨静馨

通讯作者：Yang, JX[1];Yang, JX[2];Yang, JX[3];Mikos, AG[3]

机构：[1]Beijing Engn Res Ctr, Smart Mech Innovat Design Serv, Beijing, Peoples R China;[2]Beijing Union Univ, Coll Robot, Beijing 100101, Peoples R China;[3]Rice Univ, Dept Bioengn, 6500 Main St, Houston, TX 77030 USA;[4]Tsinghua Univ, Sch Mat Sci & Engn, Beijing 100084, Peoples R China

第一机构：Beijing Engn Res Ctr, Smart Mech Innovat Design Serv, Beijing, Peoples R China

通讯机构：[1]corresponding author), Beijing Engn Res Ctr, Smart Mech Innovat Design Serv, Beijing, Peoples R China;[2]corresponding author), Beijing Union Univ, Coll Robot, Beijing 100101, Peoples R China;[3]corresponding author), Rice Univ, Dept Bioengn, 6500 Main St, Houston, TX 77030 USA.|[1141739]北京联合大学机器人学院;[11417]北京联合大学;

年份：2018

卷号：13

期号：2

外文期刊名：BIOMEDICAL MATERIALS

收录：;EI(收录号：20181004854347);Scopus(收录号：2-s2.0-85042667906);WOS:【SCI-EXPANDED(收录号:WOS:000419790900001)】；

基金：This work was supported by 2017 Beijing Municipal Education Commission scientific research project (Grant No. KM201711417015), 2017 Improve the Level of Scientific Research: Quota-Oriented Features of Discipline Research Projects by Beijing Union University (Grant No. KYDE40201708) and Premium Funding Project for Academic Human Resources Development in Beijing Union University.; JY is indebted to the China Scholarship Council and State Scholarship Fund (201608110038) for their continuous support during her fellowship at Rice University.

语种：英文

外文关键词：biodegradable magnesium; magnesium-based composites; medical application

摘要：In recent years, materials science research based on magnesium (Mg) alloys has increased significantly due to their notable advantages over traditional metals. However, magnesium alloys are susceptible to excessive degradation and subsequent disruption of mechanical integrity; this phenomenon limits the utility of these materials. Mg alloys can thus be combined with other materials to form composites for medical applications. The present article describes key advances in and considerations for the development of biodegradable Mg-based composites (BMCs). The primary characteristics of these materials include their controllable degradation rates, tunable mechanical properties, adjustable structures to promote tissue repair, improved biocompatibility, and added functionality according to the purpose of the applications. Here we provide an overview of the current research on and development status of BMCs for biomedical materials, including the present limitations and challenges of their use. Finally, this paper comprehensively discusses the most promising directions of future development for these materials.