文献类型：期刊文献

英文题名：Grape seed proanthocyanidin extract prevents DDP-induced testicular toxicity in rats

作者：Zhao, Yan-meng[1,2];Gao, Li-ping[1,2];Zhang, Hai-lian[1,2];Guo, Jun-xia[1,2];Guo, Pei-pei[1,2]

第一作者：Zhao, Yan-meng

通讯作者：Zhao, YM[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2014

卷号：5

期号：3

起止页码：605-611

外文期刊名：FOOD & FUNCTION

收录：;EI(收录号：20141017433652);Scopus(收录号：2-s2.0-84896869444);WOS:【SCI-EXPANDED(收录号:WOS:000333226000023)】；

基金：This work was supported by grants from Funding Project for Academic Human Resources Development in Beijing Union University.

语种：英文

外文关键词：Flavonoids - Oxidative stress - Rats

摘要：Oxidative stress has been proven to be involved in cisplatin (DDP)-induced toxicity. The aim of the present study was to investigate a possible protective role of grape seed proanthocyanidin extract (GSPE) in DDP-induced spermiotoxicity. GSPE at 200 mg kg(-1) d(-1) and 400 mg kg(-1) d(-1) was orally administered for 15 consecutive days, starting 10 days before a single intraperitoneal dose of DDP (7 mg kg(-1)). Results revealed that testicular and epididymal weight, epididymal sperm count, motility and morphology, the activities of GSH-Px and SOD, and GSH levels were significantly decreased whereas the level of MDA was significantly increased in the DDP group rats. GSPE treatment significantly attenuated the harmful effects of DDP-induced lipid peroxidation, oxidative stress, loss of genital organ weight, as well as function of reproductive organs. These changes were restored to near normal levels by GSPE at 400 mg kg(-1) d(-1). In conclusion, GSPE has dose dependent protective effects against DDP-induced rat testicular toxicity.