文献类型：期刊文献

英文题名：Two unusual novel iridoid glycosides from Cornus officinalis fruit and their biological activities

作者：Li, Bin[1,2];Wang, Xin[1];Lin, Peng-Cheng[3];Li, Jin-Jie[1];Luan, Na[1];Wang, Yun-Qin[1];Shang, Xiao-Ya[1]

第一作者：Li, Bin

通讯作者：Wang, X[1];Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China;[3]Qinghai Univ Nationalities, Qinghai Prov Key Lab Phytochem Tibetan Plateau, Xining 810000, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：0

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000898505200001)】；

基金：The authors gratefully acknowledge financial support from the Beijing Natural Science Foundation [No. 7214280] and the Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province [2022-ZJ-Y14].

语种：英文

外文关键词：Cornaceae; Cornus officinalis; secoiridoid glycosides; bioactivities

摘要：Two unusual novel iridoid glycosides, cornsecoside A (1) and cornsecoside B (2), were isolated from a 40% ethanol elution fraction of a 50% ethanol extract of Cornus officinalis fruit. Their structures were determined by spectroscopic data analysis combined with hydrolysis and ECD spectroscopy. In addition, compounds 1 and 2 exhibited cytotoxic activity against Bel-7402 cells with IC50 values of 8.12 and 9.31 mu M, and were neuroprotective against H2O2-induced SH-SY5Y cell injure at a concentration of 10 mu M.