文献类型：期刊文献

中文题名：密网支架治疗颅内分叉动脉瘤数值模拟研究

英文题名：Numerical simulation of intervention for cerebral bifurcate aneurysm by dense braided stent

作者：付文宇[1];李立新[1];任鹏飞[1];乔爱科[2]

第一作者：付文宇

机构：[1]北京联合大学机器人学院,北京100027;[2]北京工业大学环境与生命学部,北京100124

第一机构：北京联合大学机器人学院

年份：2020

卷号：39

期号：6

起止页码：561-568

中文期刊名：北京生物医学工程

外文期刊名：Beijing Biomedical Engineering

收录：CSTPCD;;Scopus

基金：北京市教育委员会科技计划一般项目(KM201711417011);北京联合大学百杰计划(BPHR2018CZ06)资助。

语种：中文

中文关键词：编织支架;颅内分叉动脉瘤;壁面切应力;血流速度

外文关键词：braided stent;intracranial bifurcate aneurysm;wall shear stress;blood flow speed

摘要：目的对密网支架虚拟植入颅内分叉动脉瘤过程进行数值模拟研究,探讨植入密网支架对颅内分叉动脉瘤腔的血流动力学的影响,对密网支架是否适合介入治疗颅内分叉动脉瘤进行初步的力学计算研究。方法利用有限元软件ABAQUS模拟密网支架植入颅内分叉动脉瘤的过程,得到变形后的支架模型。在ANSYS CFX中对颅内分叉动脉瘤模型及植入密网支架的分叉动脉瘤模型进行流体计算,比较植入支架前后动脉瘤腔中流线变化情况、瘤腔中血流平均速度值、动脉瘤壁面压力及壁面切应力变化情况。结果支架-微导管模型可以很好地模拟植入全过程。特别发现在载瘤动脉局部支架和血管壁贴合不良;植入支架后动脉瘤腔平均血流速度在收缩期加速和减速阶段分别降低了71.4%和17.2%;植入支架后动脉瘤面切应力降低,但壁面压力略有增加。结论密网支架可降低颅内分叉动脉瘤腔血流速度,但需特别关注密网支架和载瘤动脉局部贴合不良问题,其有可能导致载瘤动脉狭窄。
Objective The numerical simulation of the process that the braided stent is virtually implanted into the intracranial bifurcation aneurysm is carried out.The hemodynamics of the aneurismal cavity before and after the implantation of the braided stent are compared.A preliminary study of mechanical calculation is carried out whether the dense stent is suitable for interventional treatment of cerebral bifurcate aneurysm.Methods The finite element software ABAQUS is used to simulate the process of implanting dense braided stent into intracranial bifurcation aneurysm and obtain stent model implanted into parent artery.ANSYS CFX is used to perform fluid calculations on the intracranial bifurcation aneurysm model and the bifurcate aneurismal model implanted with dense braided stent.The changes of streamlines and the average speed of blood flow in the aneurismal cavity before and after the stent implantation,and the changes of the pressure and the wall shear stress on aneurismal wall are compared.Results The whole implantation process of the stent-microcatheter model is well simulated.In particular,poor apposition between stent and vessel walls are found in parent artery locally.After the braided stent implantation,the mean blood flow speed in the aneurismal cavity decreases by 71.4%and 17.2%during the systolic acceleration and deceleration phases,respectively.After the implantation of the braided stent,the aneurismal wall shear stress is reduced,the wall pressure increases slightly.Conclusions The dense braided stent can reduce the blood flow speed in the intracranial bifurcate aneurismal cavity.Special attention needs to be paid to the poor apposition between the braided stent and the parent artery,which may lead to narrowing of the parent artery.