文献类型：期刊文献

中文题名：海豹油对高脂血症大鼠和正常大鼠血脂的影响

英文题名：Effect of seal oil on blood lipids in hyperlipidemia and normal rats

作者：杨丽涛[1];刘银路[1];毕萃萃[1];魏芬芬[1];张波[1];王京钟[2]

第一作者：杨丽涛

机构：[1]北京联合大学功能食品科学技术研究院,生物活性物质与功能食品北京市重点实验室,北京100191;[2]中国疾病预防控制中心营养与健康所,北京100050

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院功能食品科学技术研究院

年份：2021

卷号：46

期号：3

起止页码：74-79

中文期刊名：中国油脂

外文期刊名：China Oils and Fats

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：校企(无极限(中国)有限公司)合作项目;北京联合大学研究生科研创新资助项目(YZ2020K001)。

语种：中文

中文关键词：高脂血症;高胆固醇血症;高甘油三酯血症;海豹油;正常饲养大鼠;胆固醇;甘油三酯

外文关键词：hyperlipidemia;hypercholesterolemia;hypertriglyceridemia;seal oil;normally fed rat;cholesterol;triglyceride

摘要：分别建立高胆固醇血症和高甘油三酯血症大鼠模型,经口给予海豹油,研究海豹油对两种模型大鼠血脂的干预作用,同时研究海豹油对正常大鼠血脂的影响。结果表明:对于高胆固醇血症大鼠,海豹油降低了大鼠血清TG、TC和LDL-C含量,高剂量组(0.67 g/kg)大鼠血清HDL-C含量显著升高(p <0.05),各剂量组大鼠血清HDL-C与TC比值均极显著升高(p <0.01);对于高甘油三酯血症大鼠,海豹油降低了大鼠血清TG和TC含量,并使血清HDL-C与TC比值极显著升高(p <0.01);对于正常饲养的大鼠,海豹油对大鼠的体重、食物利用率、脏器系数以及血清生化指标均无显著影响。综上,经口给予高胆固醇血症或高甘油三酯血症大鼠海豹油,可有效降低两种模型大鼠血清TC和TG含量,而经口给予正常饲养大鼠海豹油,不会对正常大鼠的体重、摄食、血清生化指标以及各种脏器造成影响。
Rat models of hypercholesterolemia and hypertriglyceridemia were established,and seal oil was administered orally to study the intervention effect of seal oil on the blood lipids of the two model rats. In addition,the effect of seal oil on the blood lipids of normal rats was studied. The results showed that for hypercholesterolemia rats,seal oil could reduce the TG,TC and LDL-C levels and significantly increase the ratio of HDL-C to TC (p < 0. 01) in rats,and the HDL-C level significantly increased (p < 0. 05)in the high-dose group (0. 67 g/kg) rats;for hypertriglyceridemia rats,seal oil could reduce the TG and TC levels and significantly increase the ratio of HDL-C to TC (p < 0. 01) in rats;for normally fed rats,seal oil had no significant effect on the body weight,food utilization rate,organ coefficient and serum biochemical indexes of the rats. In summary,oral administration of seal oil to hypercholesterolemia or hypertriglyceridemia rats could effectively reduce the TC and TG levels in the two model rats,while oral administration of seal oil to normal rats had no effect on the body weight,food intake,serum biochemical indexes and various organs of normal rats.