文献类型：期刊文献

英文题名：Simultaneous Determination of Ten Antibiotics in Natural Water Samples by Capillary Electrophoresis with Electrochemiluminescence Detection coupled with Hollow Fiber-Solid Phase Extraction

作者：Zhang, Wenjuan[1];Yang, Fuxiu[1];Peng, Zhaokuai[1,2];Hou, Chunjuan[1,2];Zhou, Kaowen[1,2]

通讯作者：Zhou, KW[1];Zhou, KW[2]

机构：[1]Beijing Union Univ, Biochem Engn Coll, Beijing 100023, Peoples R China;[2]Beijing Key Lab Biomass Waste Resource Utilizat, Beijing 100023, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Biochem Engn Coll, Beijing 100023, Peoples R China;[2]corresponding author), Beijing Key Lab Biomass Waste Resource Utilizat, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2020

卷号：15

期号：10

起止页码：10184-10196

外文期刊名：INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE

收录：;Scopus(收录号：2-s2.0-85092033824);WOS:【SCI-EXPANDED(收录号:WOS:000580810400047)】；

基金：This work was supported by Beijing Natural Science Foundation of China (Grant No.2152013) and Postgraduate Funding Project of BeijingUnion University (2019-068).

语种：英文

外文关键词：Antibiotic; Water sample; Hollow fiber; Solid phase extraction; Capillary electrophoresis

摘要：A novel method for simultaneous determination of ten antibiotics in natural water samples was established based on purifing and enriching by hollow fiber (HF) solid phase extraction (SPE), separating by capillary electrophoresis (CE) and detecting by electrochemiluminescence (ECL). The effects of water sample pH, extraction time and extraction temperature on the extraction efficiency of ten antibiotics were studied. The optimized parameters of SPE with 0.2 g HF were determined as follows: water sample pH 6, extraction time 40 min and extraction temperature 50 degrees C. The effects of separation buffer solution pH, ionic strength, separation voltage and additives on the separation efficiency of ten antibiotics were investigated. The selected CE separation solution is phosphate buffer solution (pH 6.5) containing 50 mmol/L NaCl and 35 mmol/L isopropanol. The separation voltage is 19 kV. All the ten antibiotics have good linear relationship. Their detection limits were 0.4 - 1.2 mu g/L. The recoveries of water samples were 81.6% - 115.7%. The method is sensitive, accurate and rapid, and can be used to determine antibiotics in natural water samples directly.