文献类型：期刊文献

英文题名：Effects of 4-Week Treadmill Running at Different Intensities on Exercise-Induced Hypoalgesia and Endogenous Pain Modulation in Healthy Individuals

作者：Xu, Zihan[1];An, Nan[1];Xu, Shuang[2];Wang, Ruyun[1];Li, Yue[3]

第一作者：Xu, Zihan

通讯作者：Li, Y[1]

机构：[1]Beijing Sport Univ, Sch Sports Med & Rehabil, Beijing, Peoples R China;[2]UCL, Div Surg & Intervent Sci, London, England;[3]Beijing Union Univ, Special Educ Coll, Beijing, Peoples R China

第一机构：Beijing Sport Univ, Sch Sports Med & Rehabil, Beijing, Peoples R China

通讯机构：[1]corresponding author), Beijing Union Univ, Special Educ Coll, Beijing, Peoples R China.|[1141759]北京联合大学特殊教育学院;[11417]北京联合大学;

年份：2026

卷号：2026

期号：1

外文期刊名：PAIN RESEARCH & MANAGEMENT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001702380100001)】；

语种：英文

外文关键词：endogenous pain modulation; exercise-induced hypoalgesia; moderate-intensity exercise; pain; treadmill running

摘要：Objectives We aimed to investigate changes in pain perception, acute exercise-induced hypoalgesia (EIH), and endogenous pain modulation responses following 4-week treadmill running exercises of different intensities in healthy individuals. Methods Fifty-six healthy individuals were included in this study. All participants were randomly assigned to a control group and three experimental groups (treadmill running at high intensity [TRH], treadmill running at moderate intensity [TRM], and treadmill running at low intensity [TRL]). All participants performed 12 treadmill running sessions within 4 weeks at different intensities based on their target heart rate (THR). A running assessment was administered 1 week before running sessions. The magnitudes of EIH, conditioned pain modulation (CPM), and temporal summation (TS) responses following regular treadmill running were assessed. Pressure pain thresholds (PPTs) or mechanical pain thresholds (MPTs) were also determined following regular treadmill running. Results All groups exhibited an EIH effect (p < 0.001, F = 9.424) with an increase in PPT and MPT during the running sessions (p = 0.004 and F = 2.084), and the TRM and TRL groups were significantly higher than the TRH group (p < 0.001). The CPM of the TRM and TRL groups significantly increased (p < 0.001), and the TS of the TRM significantly decreased (p < 0.001). Correlation analysis showed that the acute EIH-A (r = 0.724, p < 0.001), EIH-L (r = 0.726, p < 0.001), and EIH-M (r = 0.347, p = 0.009) were positively correlated with the CPM, while EIH-A (r = -0.529, p < 0.001) and EIH-L (r = -0.544, p < 0.001) were negatively correlated with the TS. Conclusion A 4-week low-to-moderate intensity treadmill running improved acute EIH response by enhancing endogenous pain modulation in healthy individuals. Future studies should consider sex, behavior, and physiological factors to provide a comprehensive understanding of the changes in EIH following regular exercises. Trial RegistrationClinicalTrials.gov identifier: ChiCTR2300074367