文献类型：期刊文献

中文题名：PM_(2.5)致心血管系统损伤及机制研究进展

英文题名：Research progress on cardiovascular system injury caused by PM_(2.5)and related mechanisms

作者：王涵[1];劳文艳[1];李松霖[1];秦菲[1];吴国浩[2]

第一作者：王涵

机构：[1]北京联合大学生物化学工程学院,北京100023;[2]北京同仁堂股份有限公司科学研究所,北京100011

第一机构：北京联合大学生物化学工程学院

年份：2023

卷号：35

期号：7

起止页码：870-875

中文期刊名：生命科学

外文期刊名：Chinese Bulletin of Life Sciences

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：北京市自然科学基金项目(7192098)。

语种：中文

中文关键词：PM_(2.5);心血管系统损伤;氧化应激;炎症;线粒体损伤;细胞凋亡

外文关键词：PM_(2.5);cardiovascular system injury;oxidative stress;inflammation;mitochondrial damage;apoptosis

摘要：细颗粒物(particulate matter,PM_(2.5))是一种严重的环境污染物质。它对机体多系统都有不良影响,而心血管系统是其主要目标,因此PM_(2.5)暴露对心血管系统的影响越来越受到人们的关注。许多研究表明PM_(2.5)与心血管疾病(cardiovascular disease,CVD)的发病率和死亡率之间具有明确的因果关系。PM_(2.5)通过氧化应激、炎症、线粒体损伤、细胞凋亡等机制对心血管系统造成损伤,成为CVD的主要死亡危险因素。本文从流行病学、动物、细胞水平的角度总结了PM_(2.5)诱导CVD机制的研究现状,为更好地了解心血管致病机理,提高公众对PM_(2.5)对CVD危害的认识,为预防、管理、治疗PM_(2.5)引起的CVD提供科学依据。
Cardiovascular system is the main target of fine particulate matter(PM_(2.5)),a serious environmental contaminant,which has adverse health effects on multiple body systems.Therefore the influence of PM_(2.5)exposure to cardiovascular system has drawn more and more attention.A unequivocal link between PM_(2.5)and morbidity and mortality of cardiovascular diseases(CVD)has been proved by a number of studies.Cardiovascular system injury was induced by PM_(2.5)through mechanisms of oxidative stress,inflammation,mitochondrial dysfunction and cell apoptosis,etc.,thus PM_(2.5)has become the main risk factor for CVD death.Current researches on mechanisms of PM_(2.5)-induced CVD were summarized from the perspectives of human epidemiology,animal and cell,to improve the public awareness to CVD induced by PM_(2.5)and provide a scientific basis for the prevention,management and treatment of CVD caused by PM_(2.5).