文献类型：期刊文献

英文题名：Natural bioactive peptides in photoaging: Multi-target mechanisms, clinical progress, and future anti-aging applications

作者：Wang, Diandian[1,2];Li, Yang[1,2];Lu, Jiamin[1,2];Zhou, Yaxi[3];Chang, Xinyue[1,2];Liu, Jiaqi[1,2];Zhang, Shaoshi[2];Yan, Wenjie[1,2]

第一作者：Wang, Diandian

通讯作者：Yan, WJ[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, Beijing 100023, Peoples R China;[3]Chinese Acad Agr Sci, State Key Lab Resource Insects, Inst Apicultural Res, Beijing 100093, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2026

卷号：114

外文期刊名：AGEING RESEARCH REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001632395500002)】；

基金：This work was supported by Key and Major Cultivation Project of Beijing Union University (ZK10202501) .

语种：英文

外文关键词：Photoaging; Ultraviolet radiation; Bioactive peptides; Sources; Mechanisms

摘要：Photoaging is a process of accelerated skin aging induced by ultraviolet radiation (UVR) and other exogenous factors, characterized by deepened wrinkles, collagen degradation, and inflammatory responses. With increasing public interest in maintaining healthy skin and delaying aging, natural proteins and their bioactive peptides have emerged as promising candidates in anti-photoaging research due to their potent antioxidant, anti-inflammatory, and extracellular matrix (ECM) metabolism-regulating activities. Therefore, this review focuses on natural antiphotoaging peptides (APPs) and summarizes the latest research advances in their application in skin photoaging, covering their sources, preparation methods, clinical studies, and anti-photoaging mechanisms. It places particular emphasis on the roles of different types of bioactive peptides in skin protection, functional regulation, and aging intervention, while also conducting an in-depth discussion on the current challenges faced in their practical applications and their prospects. The results showed that APPs can significantly alleviate skin damage caused by ultraviolet radiation through multi-target mechanisms of action, and some peptides have completed clinical validation. In the future, APPs are expected to demonstrate broad application potential in dietary nutritional interventions and anti-aging strategies.