文献类型：期刊文献

英文题名：Secoiridoid glycosides from the fruits ofCornus officinalis

作者：Wang, Xin[1];Zhong, Xiang-Jian[1];Zhou, Na[1];Ji, Lin-Lin[1];Li, Jin-Jie[1];Cai, Ning[1];Wang, Qing-Bo[2];Lin, Peng-Cheng[2];Shang, Xiao-Ya[1]

第一作者：王欣

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[2]Qinghai Univ Nationalities, Qinghai Prov Key Lab Phytochem Tibetan Plateu, Xining, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2022

卷号：36

期号：9

起止页码：2329-2335

外文期刊名：NATURAL PRODUCT RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000577390000001)】；

基金：The authors gratefully acknowledge financial supports from the Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201911417014), Premium Funding Project for Academic Human Resources Development in Beijing Union University (BPHR2019DZ02), Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (No. KZ201811417049), and the Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province (2019-ZJ-Y19).

语种：英文

外文关键词：Cornus officinalis; secoiridoid glycosides; neuroprotective activity

摘要：Five new secoiridoid glycosides, cornusphenosides E-I (1-5), were isolated and characterized from an active fraction of ethanol extract of the fruits ofCornus officinalis. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound5(when evaluated at 10 mu M) showed the neuroprotective effect against H2O2-induced SH-SY5Y cell damage.