文献类型：期刊文献

英文题名：A Three-Component Approach to (Hetero)arenes with Two N-Containing Heterocycle Motifs

作者：Zhang, Yuliang[1];Zhang, Yang[1];Qiu, Hong[1];Wang, Liqin[1];Ge, Xizhen[3];Wang, Zhen[2];Yu, Xinhong[1]

第一作者：Zhang, Yuliang

通讯作者：Yu, XH[1];Wang, Z[2];Ge, XZ[3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China;[2]Linyi Univ, Coll Pharm, Linyi 276000, Shandong, Peoples R China;[3]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China

第一机构：East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

通讯机构：[1]corresponding author), East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China;[2]corresponding author), Linyi Univ, Coll Pharm, Linyi 276000, Shandong, Peoples R China;[3]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：0

外文期刊名：SYNTHESIS-STUTTGART

收录：;EI(收录号：20223412600266);Scopus(收录号：2-s2.0-85136059925);WOS:【SCI-EXPANDED(收录号:WOS:000852015000001)】；

基金：We gratefully acknowledge financial support from the National Natural Science Foundation of China (No. 21476078), Science and Technology Commission of Shanghai Municipality (No. 12431900902) and the Key Research and Development Project of Shandong Province (No. 2017YYSP027).

语种：英文

外文关键词：three-component reaction; one-pot reaction; SNAr-decar-boxylative redox isomerization; polycyclic compounds; N-alkyl pyrroles; N-alkyl indoles

摘要：A one-pot, three-component reaction involving SNAr-decarboxylative redox isomerization starting from an electron-withdrawing group bearing fluorobenzaldehyde or fluorothiophenecarbaldehyde (electron-pair diacceptor), secondary amine, and trons-4-hydroxy-L-proline or indoline-2-carboxylic acid (electron-pair donor) has been developed to give N-[(pyrrolylmethyl)-substituted (het)aryl]- and N-[(indolylmethyl)-substituted (het)aryllpyrrolidines, -piperidines, -morpholines, and -azocanes. The highlights of this protocol are its great convenience in the simultaneous construction of a C(sp(2))-N bond and a C(sp(3))-N bond with simple operation; the reaction can be performed on a gram scale. This efficient one-pot multicomponent reaction has potential as a novel method for drug synthesis, especially involving polycyclic compounds.