文献类型：期刊文献

中文题名：半夏夏枯草合剂抗抑郁作用的药理实验研究

英文题名：Pharmacological Study on Antidepressant Effect of compound mixture of pinellia tuber and prunella spike

作者：刘冬[1];张耀[2];陈小莉[2];刘爱红[2];许建阳[3];张元[4]

第一作者：刘冬

机构：[1]贵阳中医学院药学系方药教研室,贵阳550002;[2]贵阳中医学院研究生部,贵阳550002;[3]武警总医院中西医结合科,北京100039;[4]北京联合大学生物化学工程学院,北京100023

第一机构：贵阳中医学院药学系方药教研室,贵阳550002

年份：2009

卷号：20

期号：1

起止页码：9-11

中文期刊名：武警医学

外文期刊名：Medical Journal of the Chinese People’s Armed Police Forces

收录：CSTPCD

语种：中文

中文关键词：半夏夏枯草合剂;抑郁症;药理学

外文关键词：Compound mixture of pinellia tuber and prunella spike Depression Pharmacology

摘要：目的研究半夏夏枯草合剂的抗抑郁作用。方法采用小鼠悬尾实验、小鼠强迫游泳实验、利血平诱导小鼠体温下降实验和开场实验研究半夏夏枯草合剂的抗抑郁作用。结果在小鼠悬尾实验中，半夏夏枯草合剂大剂量组能明显缩短模型小鼠的不动时间；在小鼠强迫游泳实验中，半夏夏枯草合剂大剂量组和中剂量组能明显缩短模型小鼠的不动时间；在利血平诱导的体温下降实验中，半夏夏枯草合剂大剂量组和中剂量组能明显抑制小鼠体温的下降；在开场实验中，各剂量组对小鼠的自主活动均无明显影响。结论半夏夏枯草合剂有明显的抗抑郁作用。
Objective To study the antidepressant effect of compound mixture of pinellia tuber and prunella spike （CMPP）. Methods Mice were subjected to tail suspension test, forced swimming test, reserpine - induced hypothermia test, and open field test. Results In the tail suspension test, high dose of CMPP showed significantly shortened immobility time;in the forced swimming test, high dose and medium dose of CMPP could shorten immobility time significantly;in the reserpine -induced hypothermia test, high dose and medium dose of CMPP inhibited the decline of mice＇ temperature. And in the open field test, all medicine had not obvious effect on mice＇ independent activities. Conclusions CMPP has significant antidepressant effect.