文献类型：期刊文献

英文题名：Study on Repairing Canine Mandibular Defect with Mg-Sr Alloy

作者：Wang, Cheng-Yue[1];Kang, Chun-Yu[2];Zhang, Shan-Ning[2];Yang, Jing-Xin[3,4];Cheng, Guang[3,4]

第一作者：Wang, Cheng-Yue

通讯作者：Yang, JX[1];Yang, JX[2]

机构：[1]Jinzhou Med Univ, Dept Prosthodont, Affiliated Hosp 2, Jinzhou 121000, Peoples R China;[2]Jinzhou Med Univ, Grad Sch, Jinzhou 121000, Peoples R China;[3]Beijing Union Univ, Coll Robot, Beijing 100101, Peoples R China;[4]Beijing Engn Res Ctr, Smart Mech Innovat Design Serv, Beijing 100101, Peoples R China

第一机构：Jinzhou Med Univ, Dept Prosthodont, Affiliated Hosp 2, Jinzhou 121000, Peoples R China

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Robot, Beijing 100101, Peoples R China;[2]corresponding author), Beijing Engn Res Ctr, Smart Mech Innovat Design Serv, Beijing 100101, Peoples R China.|[1141739]北京联合大学机器人学院;[11417]北京联合大学;

年份：2018

卷号：8

期号：1

起止页码：11-19

外文期刊名：JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000426615200002)】；

基金：This work was supported by the National Natural Science Foundation of China (81000520, 81471271, 30900292). This work was supported by 2017 Beijing Municipal Education Commission scientific research project (Grant No. KM201711417015). This work was supported by key project of science and technology plan of Beijing Education Committee of Beijing Natural Science Foundation (18JC0021).

语种：英文

外文关键词：Mg-Sr Alloy; Mineralized Collagen; Mandibular Defect; Bone Repair

摘要：Objective: To investigate the feasibility of the application of biodegradable Mg-Sr alloy in the repair of mandibular defects in canine. Methods: The bilateral mandibular second and third premolars of all the experimental canines were extracted. After 4 weeks, the canine model of mandible buccal fenestration bone defects were prepared. The 4 experimental canines were randomly divided into group A and B, then biodegradable Mg-Sr alloy and mineralized collagen membrane was implanted in canines of group A, while the mineralized collagen and mineralized collagen membrane was implanted in canines of group B. After 4, 8 and 12 weeks, canines were observed by cone beam computer tomography (CBCT) to measure grey value. After 12 weeks, the experimental specimens were collected to evaluate by general observation, X-ray microscope test and histological observation of hard tissue. Results: All the experimental canines were survived with good surgical healing after surgery. CBCT images show that, at each time point, the grey value of group A was higher than that of group B, and the difference was statistically significant (P < 0.05). The results of X-ray microscopy test showed that: the bone volume fraction of group A was higher than that of group B, and the difference was statistically significant (P < 0.05). The result of hard tissue slicing showed that, the newly woven bone is thick and arranged staggered in group A, while in group B, the newly woven bone was thinner than that of group A. Conclusions: Mg-Sr alloy has a good osteogenic effect for bone defects with better biocompatibility.