文献类型：期刊文献

中文题名：矿化胶原与镁钙合金的复合材料用于犬拔牙位点保存的实验研究

英文题名：Experimental study on the application of mineralized collagen and magnesium calcium alloy composite in the preservation of dog tooth extraction site

作者：于晴[1];王程越[1];杨静馨[2];郭昌武[1]

第一作者：于晴

机构：[1]锦州医科大学附属第二医院口腔修复科;[2]北京联合大学机器人学院

第一机构：锦州医科大学附属第二医院口腔修复科,辽宁锦州121000

年份：2017

卷号：35

期号：5

起止页码：532-536

中文期刊名：中国临床解剖学杂志

外文期刊名：Chinese Journal of Clinical Anatomy

收录：北大核心:【北大核心2014】；CSCD:【CSCD2017_2018】；

基金：辽宁省科学技术基金项目(2015020689)

语种：中文

中文关键词：矿化胶原;镁钙合金;拔牙位点;骨再生

外文关键词：Mineralized collagen; Calcium magnesium alloy; Tooth- extraction site ; Bone regeneration

摘要：目的研究矿化胶原复合镁钙合金用于犬拔牙位点保存的可行性。方法拔除8只杂种犬下颌双侧第4前磨牙,共32个拔牙窝(近中和远中牙槽窝各16个),随机分为A、B两组。A组植入矿化胶原复合镁钙合金材料,B组仅植入矿化胶原材料,于术后12,24周处死实验犬,制备组织标本,通过大体观察、CBCT、肝肾组织学切片观察以及X射线显微镜检测评价拔牙窝愈合情况及肝肾组织的损伤情况。结果两组材料在拔牙窝愈合过程中,逐渐被降解吸收,新生骨组织不断形成。术后12周,实验A组的相对骨密度值以及新生骨组织数量均多于B组,差异有统计学意义(P<0.05)。术后24周,A、B两组的新生骨组织数量逐渐增多,两组相对骨密度值差异不显著(P>0.05)。结论矿化胶原与镁钙合金的复合材料可用于犬拔牙位点的保存,可促进新骨再生,减缓牙槽嵴的吸收。
Objective To study the feasibility of mineralized collagen composite calcium magnesium alloy used in the preservation of dog tooth extraction site. Methods Forth premolars of eight mongrel dogs from the left and right sides of the mandible were extracted, which then resulted in a total of 32 extraction sockets that were then randomly divided into two groups, A and B, with 16 extraction sockets in each group.Group A was implanted with the composite material of mineralized collagen and calcium magnesium alloy,group B was only implanted with mineralized collagen material, the dog was sacrificed 12, 24 weeks later to prepare tissue specimens. The healing of sockets was evaluated by gross observation,CBCT and X-ray microscopes. The damage of liver and kidney tissues was observed by histological sections of liver and kidney. Results After implantation of the two groups of materials in the extraction nest, with the healing of the tooth socket, the material gradually degraded and absorbed, the new bone tissue continued to form. At 12 weeks postoperatively, the relative bone mineral density and the number of new bone tissues in experimental group A were significantly higher than those in control group B（P〈0.05）. At 24 weeks after operation, the number of new bone tissue in group A and B increased gradually, and the difference of bone mineral density between the two groups was not significant（P〈0.05）. Conclusion The composite material of mineralized collagen and calcium magnesium alloy can be used for preservation of dog ＇s tooth extraction site, which promotes the regeneration of new bone and reduces the absorption of alveolar ridge.