文献类型：期刊文献

英文题名：Biomimetic apatite formed on cobalt-chromium alloy: A polymer-free carrier for drug eluting stent

作者：Chen, Cen[1,2];Yao, Chenxue[1];Yang, Jingxin[3];Luo, Dandan[1];Kong, Xiangdong[1];Chung, Sung-Min[4];Lee, In-Seop[1,5]

第一作者：Chen, Cen

通讯作者：Lee, IS[1];Lee, IS[2]

机构：[1]Zhejiang Sci Tech Univ, Coll Life Sci, Bio X Ctr, Hangzhou 310018, Zhejiang, Peoples R China;[2]Zhejiang Prov Key Lab Silkworm Bioreactor & Biome, Hangzhou 310018, Zhejiang, Peoples R China;[3]Beijing Union Univ, Coll Mech & Elect Engn, Mat Sci & Engn, Beijing 100020, Peoples R China;[4]GENOSS Co Ltd, Biomat R&D Ctr, Suwon 443270, South Korea;[5]Yonsei Univ, Inst Nat Sci, Seoul 03722, South Korea

第一机构：Zhejiang Sci Tech Univ, Coll Life Sci, Bio X Ctr, Hangzhou 310018, Zhejiang, Peoples R China

通讯机构：[1]corresponding author), Zhejiang Sci Tech Univ, Coll Life Sci, Bio X Ctr, Hangzhou 310018, Zhejiang, Peoples R China;[2]corresponding author), Yonsei Univ, Inst Nat Sci, Seoul 03722, South Korea.

年份：2017

卷号：151

起止页码：156-164

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20165203167927);Scopus(收录号：2-s2.0-85006791277);WOS:【SCI-EXPANDED(收录号:WOS:000394475400019)】；

基金：This research was partly supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Republic of Korea (2015R1D1A1A09058875), partly by National Natural Science Foundation of China (51502265), and partly by Zhejiang Provincial Natural Science Foundation of China (LQ16E020006).

语种：英文

外文关键词：Drug-eluting stent; Polymer-free; Biomimetic apatite; Smooth muscle cell; Sirolimus

摘要：In this study, sirolimus (SRL) was loaded within biomimetic apatite formed on cobalt-chromium (Co-Cr) alloy, which has been reported for the first time, to inhibit the in-stent restenosis. Two different groups of loading SRL within biomimetic apatite were prepared: Group A (mono-layer of apatite/SRL) and Group B (bi-layer of apatite/SRL). Group A and Group B showed the biphasic pattern of SRL release up to 40 and 90 days, respectively. The attachment of human artery smooth muscle cell (HASMC) for both Group A and Group B was significantly inhibited, and proliferation dramatically decreased with the release of SRL. Noteworthily, biomimetic apatite alone also suppressed the SMC proliferation. The porous biomimetic apatite uniformly covered Co-Cr stent without crack or webbings. After balloon expansion, the integrity of biomimetic apatite was sufficient to resist delamination or destruction. Thus, this study demonstrated that biomimetic apatite is a promising drug carrier for potential use in stents. (C) 2016 Elsevier B.V. All rights reserved.