文献类型：期刊文献

英文题名：Positive intervention of insoluble dietary fiber from defatted rice bran on hyperlipidemia in high fat diet fed rats

作者：Liu, Qian[1,2];Zhao, Jieyu[1];Liu, Sushi[1];Fan, Yuchuan[1];Mei, Jiajia[1];Liu, Xuanjiang[1];Wei, Tao[1,2]

第一作者：刘倩

通讯作者：Wei, T[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[2]Beijing Union Univ, Coll Biochem Engn, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2021

卷号：86

期号：9

起止页码：3964-3974

外文期刊名：JOURNAL OF FOOD SCIENCE

收录：;Scopus(收录号：2-s2.0-85109892041);WOS:【SCI-EXPANDED(收录号:WOS:000671852700001)】；

基金：General Project of Scientific Research Program of Beijing Municipal Education Commission, Grant/Award Number: KM201811417003

语种：英文

外文关键词：anti-inflammatory; antioxidant; gut microbiota; hyperlipidemia; insoluble dietary fiber

摘要：Increasing dietary fiber intake is considered to be an effective way to prevent and relieve the diseases associated with high-income lifestyles. Compared with soluble dietary fiber, comprehensive evaluation about the effects of insoluble dietary fiber on hyperlipidemia is rarely studied. In the present study, the insoluble dietary fiber was extracted from defatted rice bran by enzymatic treatments (IDF-dRB), followed by investigation about the adsorption and antioxidant activities in vitro. Moreover, the alleviating effects of IDF-dRB on hyperlipidemia were evaluated and analyzed. As a result, IDF-dRB possessed good adsorption capacities of glucose and cholesterol, and also exhibited excellent properties in scavenging radicals. Furthermore, intervention with IDF-dRB significantly improved lipid and glucose metabolism and alleviated inflammation and oxidative stress in rats fed high-fat diet. It was also observed that IDF-dRB treatment could recover the decline in species of gut microbiota caused by high fat diet, increase the community richness, and modulate the metabolic function of gut microbiota. In conclusion, the results indicated that IDF-dRB could ameliorate hyperlipidemia from many aspects and offered some perspectives about the effects of diet intervention with insoluble dietary fiber. Practical Application Rice bran and defatted rice bran are coproducts in the rice processing industry and potentially valuable for the preparation of insoluble dietary fiber. Here an insoluble dietary fiber IDF-dRB was extracted from defatted rice bran and showed good properties in improving lipid and glucose levels, alleviating inflammation and oxidative stress, and modulating gut microbiota in rats fed high-fat diet, suggesting the potential application in ameliorating hyperlipidemia.