文献类型：期刊文献

英文题名：New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

作者：Ji, Lin-lin[1];Wang, Xin[1];Li, Jin-jie[1];Zhong, Xiang-jian[1];Zhang, Bo[1];Juan, Jing[1];Shang, Xiao-ya[1]

第一作者：Ji, Lin-lin

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2019

卷号：24

期号：3

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000458934000249)】；

基金：The authors gratefully acknowledge the grants from the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (No. KZ201811417049); the Strengthening University by Talents Program of Beijing Union University (Grant No. BPHR2018AZ01); and the Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201811417008).

语种：英文

外文关键词：Cornus officinalis; iridoid; neuroprotective activity

摘要：Three previously undescribed iridoids, cornusfurals A-C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.