文献类型：期刊文献

中文题名：Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities

英文题名：Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities

作者：Zhong Xiang-Jian[1];Zhou Na[1];Wang Xin[1];Li Jin-Jie[1];Ma Hui[2];Mao Yue[1];Xu Jia-Hui[1];Lin Peng-Cheng[3];Shang Xiao-Ya[1]

第一作者：ZHONG Xiang-Jian

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Shandong Inst Prod Qual Inspect, Jinan 250100, Peoples R China;[3]Qinghai Nationalities Univ, Key Lab Qinghai Tibet Plateau Phytochem Qinghai P, Xining 810000, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2022

卷号：20

期号：2

起止页码：155-160

中文期刊名：中国天然药物：英文版

外文期刊名：CHINESE JOURNAL OF NATURAL MEDICINES

收录：CSTPCD;;CSCD:【CSCD2021_2022】；PubMed;

基金：This work was supported by the Key Projects of Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (No. KZ201811417049) , the Scientific Research Common Program of Beijing Municipal Commission of Education (No. KM202011417014) , the Innovation Platform for the Develop-ment and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province (No. 2019-ZJ-Y19) , Beijing Union University Graduate Research and Innovation Fund Project (No. YZ2020K001) and the Academic Research Projects of Beijing Union University (No. XP202005) .

语种：英文

中文关键词：Rosmarinus officinalis;Isolation and purification;Triterpenoid;Biological activity

外文关键词：Rosmarinus officinalis; Isolation and purification; Triterpenoid; Biological activity

摘要：Three new ursane-type triterpenoids,3-oxours-12-en-20,28-olide(1),3β-hydroxyurs-12-en-20,28-olide(2)and 3β-hydroxyurs-11,13(18)-dien-20,28-olide(3),were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis.Their structures were elucidated by a combination of extensive 1D-and 2D-NMR experiments,MS data and comparisons with literature reports.Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages,but no antibacterial activity was found at a concentration of 128μg·mL^(-1).
Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3 beta-hydroxyurs-12-en-20, 28-olide (2) and 3 beta-hy-droxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis. Their structures were elucidated by a combination of extensive 1D-and 2D-NMR experiments, MS data and comparisons with literature reports. Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages, but no antibacterial activity was found at a concentration of 128 mu g.mL(-1).