文献类型：期刊文献

英文题名：Morinda officinalis oligosaccharides ameliorate corticosterone-induced depression-like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

作者：He, Mengjie[1];Liu, Zixuan[1];Chen, Yuxin[1];Wu, Xiaoru[2];Dai, Xueling[1];Liu, Qian[1];Wang, Shuo[3];Zuo, Zeping[2];Sun, Yaxuan[1]

第一作者：He, Mengjie

通讯作者：Sun, YX[1];Zuo, ZP[2]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing Key Lab Bioact Subst & Funct Food, 18 Fatou Xili 3rd Dist, Beijing 100191, Peoples R China;[2]Beijing Tongrentang Co Ltd, 20 South Third Ring Middle Rd, Beijing 100062, Peoples R China;[3]Nankai Univ, Sch Med, Tianjin Key Lab Food Sci & Hlth, Tianjin 300350, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing Key Lab Bioact Subst & Funct Food, 18 Fatou Xili 3rd Dist, Beijing 100191, Peoples R China;[2]corresponding author), Beijing Tongrentang Co Ltd, 20 South Third Ring Middle Rd, Beijing 100062, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2026

卷号：34

期号：3

外文期刊名：MOLECULAR MEDICINE REPORTS

收录：;Scopus(收录号：2-s2.0-105045050298);WOS:【SCI-EXPANDED(收录号:WOS:001814360900001)】；

基金：Not applicable.

语种：英文

外文关键词：Morinda officinalis oligosaccharides; corticosterone; depression; neuronal injury; brain-derived neurotrophic factor; gut microbiota

摘要：The aim of the present study was to elucidate the regulatory effect of Morinda officinalis oligosaccharides (MOOs) on the brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element-binding protein (CREB) signalling pathway and the gut microbiota in a corticosterone (CORT)-induced chronic stress model. Mice received subcutaneous injections of CORT for 35 days. During this period, different concentrations of MOOs were concurrently administered by gavage. The synergistic regulatory effect of MOOs on the hippocampal BDNF/TrkB/CREB signalling pathway and gut microbiota remodelling was assessed using western blotting, ELISA, 16S ribosomal RNA sequencing, H&E/Nissl staining and reverse transcription-quantitative PCR in the CORT-induced chronic stress mouse model. In this model, MOOs alleviated depression-like behaviour, promoted the expression of BDNF and neuronal nuclear antigen in the hippocampus, normalised monoamine neurotransmitter levels in the brain, activated the BDNF/TrkB/CREB signalling pathway, increased BDNF expression in the hippocampus and remodelled the intestinal microbiota, thereby exerting antidepressant effects. These results suggested that MOOs exerted antidepressant-like effects in CORT-exposed mice by attenuating hippocampal neuronal damage, activating the BDNF/TrkB/CREB signalling pathway and ameliorating gut microbiota dysbiosis. These findings provide novel evidence for the clinical application of MOOs in depression.