文献类型：期刊文献

英文题名：Lignans from the Twigs of Litsea cubeba and Their Bioactivities

作者：Li, Xiuting[1];Xia, Huan[2,3];Wang, Lingyan[2,3];Xia, Guiyang[2,3];Qu, Yuhong[2,3];Shang, Xiaoya[4];Lin, Sheng[2,3]

第一作者：Li, Xiuting

通讯作者：Lin, S[1];Lin, S[2];Shang, XY[3]

机构：[1]Beijing Technol & Business Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China;[2]Chinese Acad Med Sci, Inst Materia Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China;[3]Peking Union Med Coll, Beijing 100050, Peoples R China;[4]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China

第一机构：Beijing Technol & Business Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China

通讯机构：[1]corresponding author), Chinese Acad Med Sci, Inst Materia Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China;[2]corresponding author), Peking Union Med Coll, Beijing 100050, Peoples R China;[3]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2019

卷号：24

期号：2

外文期刊名：MOLECULES

收录：;Scopus(收录号：2-s2.0-85060109763);WOS:【SCI-EXPANDED(收录号:WOS:000457137200092)】；

基金：Financial supports from the Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (No. 20171040) and the National Natural Science Foundation of China (NNSFC; Nos. 81522050 and 81773589), and the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (No. KZ201811417049).

语种：英文

外文关键词：Litsea cubeba; cytotoxicity; isolation and elucidation; lignans

摘要：Litsea cubeba, an important medicinal plant, is widely used as a traditional Chinese medicine and spice. Using cytotoxicity-guided fractionation, nine new lignans 1-9 and ten known analogues 10-19 were obtained from the EtOH extract of the twigs of L. cubeba. Their structures were assigned by extensive 1D- and 2D-NMR experiments, and the absolute configurations were resolved by specific rotation and a combination of experimental and theoretically calculated electronic circular dichroism (ECD) spectra. In the cytotoxicity assay, 7,9-epoxylignans with feruloyl or cinnamoyl groups (compounds 7-9, 13 and 14) were selectively cytotoxic against NCI-H1650 cell line, while the dibenzylbutyrolactone lignans 17-19 exerted cytotoxicities against HCT-116 and A2780 cell lines. The results highlighted the structure-activity relationship importance of a feruloyl or a cinnamoyl moiety at C-9 or/and C-7 ketone in 7,9-epoxylignans. Furthermore, compound 11 was moderate active toward protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 13.5 M, and compounds 4-6, 11 and 12 displayed inhibitory activity against LPS-induced NO production in RAW264.7 macrophages, with IC50 values of 46.8, 50.1, 58.6, 47.5, and 66.5 M, respectively.