文献类型：期刊文献

中文题名：玛咖对运动训练大鼠睾酮及相关激素和抗疲劳能力的影响

英文题名：Effect of Lepidium meyennii on Testosterone Content,Correlated Hormones Content and Exercise Capacity in Rats Receiving Exercise Training

作者：赵裕虎[1];曹建民[2];郭娴[2];周海涛[3]

第一作者：赵裕虎

机构：[1]常州大学;[2]北京体育大学;[3]北京联合大学生物化学工程学院

第一机构：常州大学,江苏常州213164

年份：2014

卷号：20

期号：23

起止页码：164-168

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2011】；

基金：国家体育总局课题(2013A101)

语种：中文

中文关键词：玛咖;促黄体生成素;促卵泡激素;睾酮;抗疲劳

外文关键词：Lepidium meyennii ; luteinizing homone; follicle-stimulating hormone; testosterone; anti-fatigue

摘要：目的:研究玛咖对运动训练大鼠睾酮及相关激素含量和抗疲劳能力的影响。方法:以大强度耐力训练大鼠为模型,55只42 d龄雄性Wistar大鼠为对象,随机分为5组:静止组、运动组、运动+低剂量玛咖组,运动+中剂量玛咖组,运动+高剂量玛咖组,每组10只(剔除不符合实验要求的大鼠5只)。每天灌胃(ig)1次,玛咖组剂量分别为0.2,0.4,1.2 g·kg-1,灌胃体积5 m L·kg-1,静止组,运动组ig等量生理盐水。42 d力竭游泳训练后,测定体重、力竭游泳时间及血睾酮等生化指标。结果:体重,运动组小于静止组(P<0.05);玛咖各组大于运动组(P<0.05),玛珈各剂量组间无显著差异。力竭游泳时间,运动组与静止组无明显差异;玛咖各组明显长于运动组(P<0.01),且随剂量增大而延长。血清睾酮水平,运动组低于静止组(P<0.01);玛咖各组分别为(4.78±1.58),(4.95±1.54),(5.06±1.59)nmol·L-1,高于运动组(P<0.01),且玛咖各组组间无显著差异。血清皮质酮水平,各组间均无显著差异。血清睾酮与皮质酮比值变化与睾酮变化较为一致。血清促黄体生成素、促卵泡激素水平,静止组高于运动组,但无显著差异;玛咖各组高于运动组(P<0.01),且玛咖各组组间无显著差异。结论:补充玛咖可以纠正由于运动导致的下丘脑-垂体-性腺轴功能的紊乱,有效预防血清睾酮水平的降低,进而增强抗疲劳能力。
Objective ： To study the effects of Lepidium meyennii on the content of testosterone, correlated hormones and anti-fatigue ability of rats after exercise. Method： By using the model of high-intensity endurance training, fifty-five 6-week-old male Wistar rats were randomly divided into 5 groups, with 10 in each group （5 rats which did not meet the requirement were removed） ： still in control group （C group） , motion control group （M group） , exercise ＋ ig low-dose L. meyennii group （ OML group） , exercise ＋ ig middle-close L. meyennii group （OMM group）, and exercise ＋ ig high-dose L. meyennii group （OMH group）. Gavage was performed using professional device once a day. The rats in L. meyennii groups were gavaged with 0. 2, 0. 4, 1.2 g ·kg^-1 with ig volume of 5 mL ·kg^-1 The rats in C and M groups were given saline of same volume. After 42 clays of exhaustive swimming training, body weight, swimming time and serum testosterone and other biochemical markers were measured. Result ： Body weight of the rats in M groups was lower than those in C group （P 〈 0.05） , and those in all doses of L. meyennii groups were higher than in M group （P 〈 0.05） which did not show any differences among groups. Swimming time in all doses of L. meyennii groups were longer than in M group （P 〈 0.01 ） , and there were dose-response. But there were no differences between C and M groups. Serum testosterone in M group was lower than C group （P 〈 0.01 ） , in the same time, serum testosterone were higher in all doses of L. meyennii groups than M group [OML： （4.78±1.58） nmol·L^-1; OMM： （4.95±1.54） nmol·L^-1; OMH： （5.06±1.59） nmol·L^-1, P 〈0.01 ]. The serum corticosterone levels in each group showed no significant differences. Changes in the ratio of serum testosterone/corticosterone were more consistent with testosterone changes among the groups. There were no differences in luteinizing hormone and follicle-stimulating hormone among C group and M group. But luteinizing hormone in all doses of L. meyennii groups were higher than in M group （P 〈 0. 01 ）. In the mean time, follicle-stimulating hormone in all doses of L. meyennii groups were higher than in M group （P 〈 0.01 ）. There were no differences in both luteinizing hormone and follicle-stimulating hormone between groups in all doses of L. meyennii groups. Conclusion： The supplement of L. meyennii can alleviate the hypothalamus-pituitary-gonad axis function disorder caused by exercise through multiple targets and multiple ways. Finally, L. meyennii can prevent the decrease of serum testosterone after high-intensity exercise and improve anti-fatigue ability.