文献类型：期刊文献

英文题名：Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of Ainsliaea yunnanensis

作者：Li, Jinjie[1];Li, Xiuting[2];Wang, Xin[1];Zhong, Xiangjian[1];Ji, Linlin[1];Guo, Zihan[1];Liu, Yiran[1];Shang, Xiaoya[1]

第一作者：李金杰

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Technol & Business Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2019

卷号：24

期号：9

外文期刊名：MOLECULES

收录：;Scopus(收录号：2-s2.0-85065640369);WOS:【SCI-EXPANDED(收录号:WOS:000469518100060)】；

基金：This research was funded by Scientific Research Common Program of Beijing Municipal Commission of Education [No. KM201811417008], the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee [No. KZ201811417049], the Strengthening University by Talents Program of Beijing Union University [Grant No. BPHR2019DZ03], and the Strengthening University by Talents Program of Beijing Union University [Grant No. BPHR2018AZ01]; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University [No. 20171040].

语种：英文

外文关键词：Ainsliaea yunnanensis; sesquiterpenoids; structures; inflammasome

摘要：Four new sesquiterpenoids (1-4) and six known sesquiterpenoids (5-10), were isolated from the EtOAc phase of the ethanolic extract of Ainsliaea yunnanensis. Their structures were established by spectroscopic methods, including 1-D, 2-D NMR and HPLC-MS. All compounds were tested for their anti-inflammatory effect by the inhibition of the activity of NLRP3 inflammasome by blocking the self-slicing of pro-caspase-1, which is induced by nigericin, then the secretion of mature IL-1, mediated by caspase-1, was suppressed. Unfortunately none of the compounds showed an anti-inflammatory effect.