文献类型：期刊文献

英文题名：The effects of vitamin C on DDP-induced anemia in rats

作者：Gao, Li-Ping[1,2];Li, Zen[1,2];Guo, Zhuo-Yu[1,2];Zhao, Yan-Meng[1,2]

第一作者：高丽萍

通讯作者：Gao, LP[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2013

卷号：23

期号：6

起止页码：383-388

外文期刊名：TOXICOLOGY MECHANISMS AND METHODS

收录：;Scopus(收录号：2-s2.0-84879681048);WOS:【SCI-EXPANDED(收录号:WOS:000321065600001)】；

基金：This work was supported by grants from the Talents Support Project of Talents Enhancing University Development Plan in Beijing Union University (BPHR2011A01).

语种：英文

外文关键词：Anemia; DDP; erythropoietin; nephrotoxicity; vitamin C

摘要：The aim of this study was to investigate the effects of vitamin C on cisplatin (DDP)-induced anemia and explore its possible mechanisms in rats. Adult male Sprague-Dawley rats were randomly divided into six groups: control, vitamin C 50, vitamin C 100, DDP, DDP plus vitamin C 50 and DDP plus vitamin C 100-treated groups. DDP was intravenous injected as a single dose and vitamin C was administered by gavage. Serum erythropoietin (Epo), hemoglobin (Hb) and blood urea nitrogen (BUN) concentration were measured 4 and 14 days after DDP treatment. The changes of renal tissue were examined by light microscope. Administration of DDP to rats induced anemia and nephrotoxicity, characterized with a significant decrease in serum Epo and Hb and increase in BUN concentrations. Pathological examination revealed that DDP caused significant renal damage in rats. Vitamin C administration produced amelioration in biochemical indices of anemia and nephrotoxicity and in histological change when compared to group DDP alone; concurrent administration of vitamin C at doses of 100 mg/kg being more effective. Results from this study indicate that the novel natural antioxidant vitamin C might have protective effect against DDP-induced anemia in rats.