文献类型：期刊文献

中文题名：甲壳低聚糖对糖尿病小鼠降糖作用的实验研究

英文题名：An experimental study on the effects of Chitooligosaccharides on blood glucose in mice

作者：林强[1];张元[1];崔玉梅[1]

机构：[1]北京联合大学生物化学工程学院

第一机构：北京联合大学生物化学工程学院

年份：2008

卷号：33

期号：8

起止页码：251-253

中文期刊名：食品科技

外文期刊名：Food Science and Technology

收录：北大核心:【北大核心2004】；

基金：北京市教委科技成果转化立项项目

语种：中文

中文关键词：甲壳低聚糖;四氧嘧啶;降血糖作用;糖尿病

外文关键词：chitooligosaccharides; alloxan; declining blood-glucose effects; diabetes

摘要：研究分子量为1500u的甲壳低聚糖对ICR高血糖小鼠的降糖作用。方法:通过小鼠腹腔注射四氧嘧啶(200mg/kg)诱导糖尿病模型小鼠,随机分为模型对照组、阳性药物拜糖苹组(20mg/kg)、甲壳低聚糖高(200mg/kg)、中(100mg/kg)、低(50mg/kg)剂量组及空白对照组。灌胃(ig)给药28d,于14、28d测量血糖。结果:1500u甲壳低聚糖高、中剂量具有一定降糖作用,低剂量降糖不明显。结论:1500u甲壳低聚糖对四氧嘧啶高血糖小鼠具有一定的治疗和控制血糖作用。
To investigate the effects of the formula weight with 1500 u chitooligosaccharides on blood glucose level in ICR mice. Methods：Alloxan（200 mg/kg） was injected into the random of mice to induce diabetic model and the models were divide into different groups, the chitooligosaccharides groups （200, 100, 50 mg/kg）, the glybenclamide group（20 mg/kg）, the normal saline group and the model. The blood glucose was detected after mice were treated with drugs in 14 days and 28 days. Results： The chitooligosaccharides could remarkably decrease the blood-glucose of diatetic mice. Best dose were 200 mg/kg and 100 mg/kg. Conclusion： The chitooligosaccharides had significanteffects of lowering blood-glucose action on diabeticmice and was probably worthy to be developed into heath-foods.