文献类型：期刊文献

英文题名：Catanionic vesicles from an amphiphilic prodrug molecule: a new concept for drug delivery systems

作者：Jiang, Yue[1,2];Luan, Yuxia[1,2];Qin, Fei[3];Zhao, Lanxia[1,2];Li, Zhonghao[4]

第一作者：Jiang, Yue

通讯作者：Jiang, Y[1]

机构：[1]Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China;[2]Shandong Univ, Ctr Pharmaceut Res & Drug Delivery Syst, Jinan 250012, Shandong, Peoples R China;[3]Beijing Union Univ, Dept Food Sci, Coll Arts & Sci, Beijing 100191, Peoples R China;[4]Shandong Univ, Sch Mat Sci & Engn, Jinan 250061, Peoples R China

第一机构：Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China

通讯机构：[1]corresponding author), Shandong Univ, Sch Pharmaceut Sci, 44 W Wenhua Rd, Jinan 250012, Shandong, Peoples R China.

年份：2012

卷号：2

期号：17

起止页码：6905-6912

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20124715699608);Scopus(收录号：2-s2.0-84869155422);WOS:【SCI-EXPANDED(收录号:WOS:000306669300030)】；

基金：This work is supported by the National Natural Science Foundation of China (NSFC, No. 20803044, 21173127), the Natural Science Foundation of Shandong Province (ZR2011BQ003) and the Independent Innovation Foundation of Shandong University (IIFSDU, 2012TS099).

语种：英文

外文关键词：Biocompatibility - Differential scanning calorimetry - Drug products - Dynamic light scattering - Fourier transform infrared spectroscopy - High resolution transmission electron microscopy - Molecules - Nuclear magnetic resonance - Oleic acid - Scanning electron microscopy - Surface active agents - Synthesis (chemical) - Targeted drug delivery - Toxicity

摘要：Toxicity and low entrapment efficiency are the main problems for pharmaceutical applications of catanionic vesicles. In order to minimize surfactant toxicity, increase the drug loading content and simultaneously reduce the need for tedious chemical synthesis, we use oleic acid as the biocompatible surfactant, which reacts with the selected drug molecules (amlodipine) to produce an amphiphilic prodrug molecule for the straightforward fabrication of catanionic vesicles. The prodrug molecules are easily obtained by proton transfer between amlodipine and oleic acid molecules. The characterization of prodrug molecules and their aggregation behaviours in aqueous solutions are investigated by using Fourier transform infrared spectrophotometry (FTIR), H-1-nuclear magnetic resonance (H-1-NMR), differential scanning calorimetry (DSC), surface tension measurement, transmission electron microscopy (TEM), dynamic light scattering (DLS), conductivity and zeta potential (zeta). The results demonstrate that vesicles could be easily formed with the prodrug amphiphilic molecules dispersed in aqueous solutions. Particularly, the drug release behaviour of the as-prepared catanionic vesicles exhibits excellent sustained drug release properties, which demonstrates their promising application in the newly designed drug delivery system.