文献类型：期刊文献

中文题名：左房室瓣环钙化与肾功能的关系研究

英文题名：Relationship between Mitral Annular Calcification and Renal Function

作者：苗莉[1];王晨生[2];石峰[3]

第一作者：苗莉

机构：[1]北京联合大学门诊部;[2]河北医科大学附属石油医院超声科;[3]河北医科大学附属石油医院肾内科

第一机构：北京联合大学校医院

年份：2012

卷号：15

期号：8

起止页码：857-859

中文期刊名：中国全科医学

外文期刊名：Chinese General Practice

收录：CSTPCD;;Scopus;北大核心:【北大核心2011】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：左房室瓣环钙化;慢性肾脏疾病;超声心动描记术;血清肌酐;肾小球滤过率

外文关键词：Mitral annular calcification; Chronic kidney disease; Echocardiography; Serum creatine; Glomerularfiltration rate

摘要：目的探讨左房室瓣环钙化(MAC)与慢性肾功能不全之间的相关性。方法选择河北医科大学附属石油医院肾内科住院期间进行超声心动图检查发现有MAC的患者82例(MAC组),根据瓣环受累的部位不同分为仅后叶瓣环受累的局限组和前后叶瓣环均受累的广泛组。选取无MAC患者73例为对照组。测定患者的血清肌酐水平并计算肾小球滤过率(eGFR)。结果 MAC组的肌酐水平高于对照组(95μmol/L∶86μmol/L,P<0.001),而eGFR低于对照组(55.8 ml/min∶65.7 ml/min,P=0.005)。57%的MAC患者存在慢性肾脏疾病,即GFR<60 ml/min,发生率是对照组(40%)的1.4倍(P<0.05)。MAC广泛组与局限组eGFR分别为58.6 ml/min和43.2 ml/min,差异有统计学意义(P<0.05)。eGFR和MAC程度呈负相关(rs=-0.28,P<0.001)。结论 MAC与肾脏功能之间存在显著相关性。MAC的存在提示临床医生应警惕慢性肾脏疾病的可能。
Objective To explore the relationship between mitral annular ealeitication（MAC） and renal dyslunction. Methods Eighty -two patients with eehocardiographically confirmed MAC were enrolled in this study. Based on the scope of MAC, they were further divided into limitation group, in which the calcification was largely limited to the posterior annulus, andextensive group, in which the calcification was extended to the anterior annulus. Seventy -three patients without MAC were en- rolled as the control group. Serum creatine level was determined and glomerular filtration rate （GFR） was calculated. Results Serum creatine level in MAC group was significantly higher than that in control group （95 μmol/L vs 86 μmol/L, P 〈 0. 001 ）,while GFR was significantly lower （55.8 mL/min vs 65.7 ml/min, P = O. 005）. It was found 57% of the MAC patients had chronic kidney disease （GFR 〈60 ml/min）, which was 1.4 times as much as that in the control group （40%） （P 〈0. 05）. GFR in MAC extensive group and MAC limitation group were 58.6 ml/min and 43.2 ml/min, respectively （P 〈 0. 05 ）. TheGFR level and MAC level were negatively correlated （rs = -0. 28, P 〈0. 001 ）. Conclusion MAC is correlated with chronic kidney disease. The existence of MAC may suggest the possible chronic kidney disease.