文献类型：期刊文献

英文题名：Electroacupuncture treatment can improve cognitive impairment in spontaneously hypertensive rats: a preliminary DTI study

作者：Liu, Ji-peng[1];Han, Bing-xuan[1];Liu, Yu[2];Nie, Bin-bin[3];Bian, Tao[4];Liu, Chuan[5];Xia, Tian-qi[5];Gong, Yu[1];Tu, Long-teng[1];Zhang, Jing[1];Wang, Bing-hui[1];Yang, Yi[1];Li, Song-Li[1];He, Lin-ding[1];Liu, Qing-guo[1];Xu, Meng[6]

第一作者：Liu, Ji-peng

通讯作者：Liu, QG[1];Xu, M[2]

机构：[1]Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China;[2]Beijing Union Univ, Coll Special Educ, Beijing, Peoples R China;[3]Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R China;[4]Rulin Community Hlth Ctr, Beijing, Peoples R China;[5]Wangjing Community Hlth Ctr, Beijing, Peoples R China;[6]Beijing Univ Chinese Med, Affiliated Hosp 3, Dept Tuina, Beijing, Peoples R China

第一机构：Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China

通讯机构：[1]corresponding author), Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China;[2]corresponding author), Beijing Univ Chinese Med, Affiliated Hosp 3, Dept Tuina, Beijing, Peoples R China.

年份：2025

卷号：19

外文期刊名：FRONTIERS IN NEUROSCIENCE

收录：;Scopus(收录号：2-s2.0-105015558117);WOS:【SCI-EXPANDED(收录号:WOS:001568200800001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was funded by grants from the National Natural Science Foundation of China (No. 82074553), Beijing University of Traditional Chinese Medicine Special Funds for Scientific Research Operating Expenses (No. 2024-JYB-JBZD-025), and Beijing Natural Science Foundation (No. 7242231).

语种：英文

外文关键词：hypertension; impairment of cognitive function; electroacupuncture; diffusion tensor imaging (DTI); white matter structure; SHRs

摘要：Background Hypertension is a significant risk factor for cognitive impairment. Our group's previous rs-fMRI study has found that acupuncture can enhance the functional connectivity of brain regions related to cognitive function, thereby protecting the cognitive function of spontaneously hypertensive rats (SHRs).Methods This study aimed to reveal the effects of electroacupuncture on the white matter structure in the brain regions of SHRs using the diffusion tensor imaging (DTI) technique. 20 SHRs were divided into the electroacupuncture group (EA) and the model group (SHR), and 10 Wistar-Kyoto rats were established as the normal control group (WKY). Electroacupuncture was applied to Taichong (LR3) and Zusanli (ST36) acupoints for 12 weeks, with treatment every other day. Blood pressure was measured once every 2 weeks, with DTI scans and the Morris water maze (MWM) tests performed at the end of the 12-week electroacupuncture intervention.Results The results showed that electroacupuncture significantly decreased systolic and diastolic blood pressure and enhanced spatial learning and memory in SHRs. DTI analysis revealed that hypertension led to increased axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) values in brain regions such as the hippocampus, prefrontal cortex, striatum, amygdaloid body, posterior lobe of cerebellum, olfactory bulb, and piriform cortex, indicating white matter microstructural damage. Electroacupuncture improved these injuries, especially significantly improving the integrity of the hippocampal white matter structure. Correlation analysis showed that hippocampal white matter structure parameters were significantly correlated with behavioral manifestations of MWM.Conclusion Therefore, we speculate that electroacupuncture can alleviate white matter damage in the hippocampus, prefrontal cortex, striatum, and other brain regions, thereby preventing cognitive impairment in SHRs, which may be one of the reasons for the efficacy of electroacupuncture.