文献类型：期刊文献

英文题名：Harnessing Hafnium-Based Nanomaterials for Cancer Diagnosis and Therapy

作者：Ding, Shuaishuai[1,2,3];Chen, Lei[1];Liao, Jing[2,3,4,5];Huo, Qing[6];Wang, Qiang[4,5];Tian, Gan[2,3,7];Yin, Wenyan[1]

第一作者：Ding, Shuaishuai

通讯作者：Yin, WY[1];Tian, G[2];Tian, G[3];Tian, G[4]

机构：[1]Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China;[2]Army Med Univ, Third Mil Med Univ, Affiliated Hosp 1, Inst Pathol,Minist Educ China, Chongqing 400038, Peoples R China;[3]Army Med Univ, Third Mil Med Univ, Affiliated Hosp 1, Southwest Canc Ctr,Key Lab Tumor Immunopathol,Mini, Chongqing 400038, Peoples R China;[4]Capital Normal Univ, Dept Chem, Lab Microsized Funct Mat, Beijing 100048, Peoples R China;[5]Capital Normal Univ, Coll Elementary Educ, Beijing 100048, Peoples R China;[6]Beijing Union Univ, Coll Biochem & Engn, Beijing 100023, Peoples R China;[7]Chongqing Inst Adv Pathol, Jinfeng Lab, Chongqing 401329, Peoples R China

第一机构：Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

通讯机构：[1]corresponding author), Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China;[2]corresponding author), Army Med Univ, Third Mil Med Univ, Affiliated Hosp 1, Inst Pathol,Minist Educ China, Chongqing 400038, Peoples R China;[3]corresponding author), Army Med Univ, Third Mil Med Univ, Affiliated Hosp 1, Southwest Canc Ctr,Key Lab Tumor Immunopathol,Mini, Chongqing 400038, Peoples R China;[4]corresponding author), Chongqing Inst Adv Pathol, Jinfeng Lab, Chongqing 401329, Peoples R China.

年份：0

外文期刊名：SMALL

收录：;EI(收录号：20231513870208);Scopus(收录号：2-s2.0-85151973310);WOS:【SCI-EXPANDED(收录号:WOS:000963540500001)】；

基金：Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (22175182, U1932112, 81971747, 82103688), the Sheng Yuan Cooperation (2021SYHZ0048), and the Chongqing Natural Science Foundation (cstc2020jcyj-msxmX0061).

语种：英文

外文关键词：combination therapy; diagnosis; hafnium; Hf-metal-organic frameworks; nanoscaled coordination polymers; HfO2; radiotherapy

摘要：With the rapid development of nanotechnology and nanomedicine, there are great interests in employing nanomaterials to improve the efficiency of disease diagnosis and treatment. The clinical translation of hafnium oxide (HfO2), commercially namedas NBTXR3, as a new kind of nanoradiosensitizer for radiotherapy (RT) of cancers has aroused extensive interest in researches on Hf-based nanomaterials for biomedical application. In the past 20 years, Hf-based nanomaterials have emerged as potential and important nanomedicine for computed tomography (CT)-involved bioimaging and RT-associated cancer treatment due to their excellent electronic structures and intrinsic physiochemical properties. In this review, a bibliometric analysis method is employed to summarize the progress on the synthesis technology of various Hf-based nanomaterials, including HfO2, HfO2-based compounds, and Hf-organic ligand coordination hybrids, such as metal-organic frameworks or nanoscaled coordination polymers. Moreover, current states in the application of Hf-based CT-involved contrasts for tissue imaging or cancer diagnosis are reviewed in detail. Importantly, the recent advances in Hf-based nanomaterials-mediated radiosensitization and synergistic RT with other current mainstream treatments are also generalized. Finally, current challenges and future perspectives of Hf-based nanomaterials with a view to maximize their great potential in the research of translational medicine are also discussed.