文献类型：期刊文献

中文题名：乳双歧杆菌、凝结魏茨曼氏菌、植物乳植杆菌及其复合菌粉增强小鼠免疫功能研究

英文题名：Effect of Bifidobacterium animalis subsp.lactis,Weizmannia coagulans,Lactiplantibacillus plantarum and combination on regulating immune function in mice

作者：王婷婷[1];张迪[2];徐英[2];李守远[2];林钟润[2];张世奇[2];赵建[3]

第一作者：王婷婷

机构：[1]北京韩美药品有限公司,北京101312;[2]北京科丽科技有限公司,北京101318;[3]北京联合大学生物化学工程学院,北京100023

第一机构：北京韩美药品有限公司,北京101312

年份：2025

卷号：53

期号：5

起止页码：19-24

中文期刊名：中国乳品工业

外文期刊名：China Dairy Industry

收录：;北大核心:【北大核心2023】；

基金：“十四五”国家重点研发计划重点专项(2023YFF1103803)。

语种：中文

中文关键词：动物双歧杆菌乳亚种;凝结魏茨曼氏菌;植物乳植杆菌;枯草芽胞杆菌二联活菌(妈咪爱);免疫力

外文关键词：Bifidobacterium animalis subsp.lactis;Weizmannia coagulans;Lactiplantibacillus plantarum;combined Bacillus subtilis and Entercoccus faecium;immunity

摘要：文章研究动物双歧杆菌乳亚种HOM2120、凝结魏茨曼氏菌HOM5301、植物乳植杆菌HOM2217及3株菌复合菌粉在增强免疫力功能方面的作用。采用经口灌胃给予方式,以灌服生理盐水为阴性对照,市售枯草芽胞杆菌二联活菌(妈咪爱)为商品对照,设置动物双歧杆菌乳亚种HOM2120单菌粉组,凝结魏茨曼氏菌HOM5301单菌粉组,植物乳植杆菌HOM2217单菌粉组及3株菌复合菌粉组,从小鼠体质量、细胞免疫、体液免疫、单核-巨噬细胞吞噬活性、NK细胞活性等方面综合评价其对小鼠免疫功能的影响。结果表明,动物双歧杆菌乳亚种HOM2120单菌粉和凝结魏茨曼氏菌HOM5301单菌粉均能增强小鼠细胞免疫功能和小鼠单核-巨噬细胞功能;植物乳植杆菌HOM2217单菌粉能增强小鼠单核-巨噬细胞功能;枯草芽胞杆菌二联活菌(妈咪爱)和动物双歧杆菌乳亚种HOM2120、凝结魏茨曼氏菌HOM5301、植物乳植杆菌HOM2217 3株复合菌粉均能增强小鼠细胞免疫功能、体液免疫功能和小鼠单核-巨噬细胞功能。可见受试菌株均具有免疫增强功能,动物双歧杆菌乳亚种HOM2120、凝结魏茨曼氏菌HOM5301、植物乳植杆菌HOM2217 3株菌复合菌株效果优于单一菌株。
To investigate the effects of Bifidobacterium animalis subsp.lactis HOM2120,Weizmannia coagulans HOM5301,Lactiplantibacillus plantarum HOM2217 and their combined powder on enhancing immune function.Methods normal saline was used as negative control,and commercial combined Bacillus subtilis and Entercoccus faecium(Medilac-Vita)was used as reference control.B.lactis HOM2120,W.coagulans HOM5301,Lact.plantarum HOM2217 and their combined powder groups were set up.The body weight,cellular immunity,humoral immunity,monocyte-macrophage phagocytic activity,and NK cell activity were comprehensively evaluated.Results B.lactis HOM2120 and W.coagulans HOM5301 could increase the cellular immune function and mononuclear-macrophages function of mice.Lact.plantarum HOM2217 could increase mononuclear-macrophages function of mice.The Medilac-Vita and the combined powder of B.lactis HOM2120,W.coagulans HOM5301 and Lact.plantarum HOM2217 could enhance the cellular immune function,humoral immune function and mononuclear-macrophages function of mice.The resullts showed that strains havea certain immune-enhancing effect,and the combination of B.lactis HOM2120,W.coagulans HOM5301 and Lact.plantarum HOM2217 is better than any single strain.